Mesoporous Silica Nanoparticles in Biomedical Applications
Mesoporous Silica Nanoparticles in Biomedical Applications
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DOI：
10.1002/chin.201227258
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发表时间：
2012-07
期刊：
影响因子：
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通讯作者：
Zongxi Li;J. C. Barnes;Aleksandr Bosoy;J. Stoddart;J. Zink
中科院分区：
文献类型：
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作者：
Zongxi Li;J. C. Barnes;Aleksandr Bosoy;J. Stoddart;J. Zink
本教程综述提供了目前用于治疗诊断目的的纳米材料的前景，特别关注基于介孔二氧化硅纳米颗粒（MSNP）的材料。具有大表面积和孔体积的MSNPs可以作为各种治疗剂的有效载体。用分子、超分子或聚合物部分官能化MSNPs为材料提供了极大的通用性，同时执行药物递送任务，这使得递送过程高度可控。这个新兴的化学和生命科学的接口领域为研究人员提供了广泛的机会，从溶胶-凝胶科学，纳米材料的制造，超分子化学，可控药物输送和生物学和医学中的靶向治疗诊断学。
This tutorial review provides an outlook on nanomaterials that are currently being used for theranostic purposes, with a special focus on mesoporous silica nanoparticle (MSNP) based materials. MSNPs with large surface area and pore volume can serve as efficient carriers for various therapeutic agents. The functionalization of MSNPs with molecular, supramolecular or polymer moieties, provides the material with great versatility while performing drug delivery tasks, which makes the delivery process highly controllable. This emerging area at the interface of chemistry and the life sciences offers a broad palette of opportunities for researchers with interests ranging from sol–gel science, the fabrication of nanomaterials, supramolecular chemistry, controllable drug delivery and targeted theranostics in biology and medicine.