Astrocytic necrosis is induced by anti-aquaporin-4 antibody-positive serum
Astrocytic necrosis is induced by anti-aquaporin-4 antibody-positive serum
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DOI：
10.1097/wnr.0b013e32832776f4
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发表时间：
2009-03-25
期刊：
影响因子：
1.7
通讯作者：
Sakoda, Saburo
中科院分区：
文献类型：
--
作者：
Kinoshita, Makoto;Nakatsuji, Yuji;Sakoda, Saburo
视神经脊髓炎（NMO）是一种中枢神经系统的炎症性脱髓鞘疾病，体液免疫在发病机制中发挥着重要作用。在 NMO 患者血清中鉴定出抗水通道蛋白 4 抗体（AQP4-Ab，视神经脊髓炎免疫球蛋白 G），引发了对该自身抗体致病性的研究。最近的免疫组织学分析揭示了星形胶质细胞上 AQP4 的主要缺失以及 NMO 活动性病变中的补体沉积。在本报告中，我们表明星形胶质细胞对 AQP4-Ab 阳性患者的血清敏感，并以补体依赖性方式发生坏死。我们的结果表明 AQP4-Ab 在 NMO 中的主要致病作用。 NeuroReport 20:508-512 (C) 2009 Wolters Kluwer Health 垂直条 Lippincott Williams & Wilkins。
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system, and humoral immunity is suggested to play an important role in the pathogenesis. The identification of an anti-aquaporin-4 antibody (AQP4-Ab, neuromyelitis optica immunoglobulin G) in the sera of patients with NMO has led to the investigation on the pathogenicity of the autoantibody. Recent immunohistological analyses revealed the primary loss of AQP4 on astrocytes and complement deposition in active lesions of NMO. In this report, we show that astrocytes are susceptible to sera from AQP4-Ab-positive patients and undergo necrosis in a complement-dependent manner. Our results suggest the primary pathogenic role of AQP4-Ab in NMO. NeuroReport 20:508-512 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.