Clinical significance of coagulase-negative staphylococci isolates from nosocomial bloodstream infections
Clinical significance of coagulase-negative staphylococci isolates from nosocomial bloodstream infections
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DOI：
10.3109/23744235.2015.1122833
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发表时间：
2016-05-03
影响因子：
5.8
通讯作者：
Hasan, Syed Mujeeb
中科院分区：
文献类型：
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作者：
Asaad, Ahmed Morad;Qureshi, Mohamed Ansar;Hasan, Syed Mujeeb
背景 将凝固酶阴性葡萄球菌 (CoNS) 鉴定为医院病原体或污染物对于微生物学家和临床医生具有重要意义。本研究旨在确定来自医院血流感染 (BSI) 的 CoNS 分离株的分离频率和抗菌药物耐药模式，并确定与沙特三级护理医院中这些新出现的病原体引起的真正菌血症相关的危险因素。方法 在 10 个月内，使用标准方法对住院患者的所有 CoNS 阳性培养物进行鉴定。使用参考肉汤微量稀释法进行抗菌药物敏感性测试。结果 共鉴定出208株菌株；其中 75 例 (32.2%) 被认为与感染相关，133 例 (67.8%) 被认为是污染。表皮葡萄球菌占菌血症病例的 34.7%，其次是人型链球菌（21.3%）、溶血链球菌（16%）和腐生链球菌（12%）。中心静脉导管 (p
Background Identification of coagulase-negative staphylococci (CoNS) as nosocomial pathogens or contaminants is significant for microbiologists and clinicians. This study aimed to determine the frequency of isolation and antimicrobial resistance patterns of CoNS isolates from nosocomial bloodstream infections (BSIs) and to identify risk factors associated with true bacteremia caused by these emerging pathogens in a Saudi tertiary care hospital. Methods All CoNS-positive cultures from inpatients were identified using the standard methods during a 10-month period. Antimicrobial susceptibility testing was done using the reference broth microdilution method. Results A total of 208 isolates were identified; of these 75 (32.2%) were considered infection associated, and 133 (67.8%) were considered contamination. S. epidermidis accounted for 34.7% of bacteremia cases, followed by S. hominis (21.3%), S. haemolyticus (16%), and S. saprophyticus (12%). Central venous catheters (p