Hospitalizations for fractures after renal transplantation in the United States
Hospitalizations for fractures after renal transplantation in the United States
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DOI：
10.1016/s1047-2797(01)00226-5
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发表时间：
2001-10-01
影响因子：
5.6
通讯作者：
Duncan, WE
中科院分区：
文献类型：
--
作者：
Abbott, KC;Oglesby, RJ;Duncan, WE
目的：调查肾移植受者骨折的发生率、风险因素以及相关死亡率。
方法：对美国肾脏数据系统（USRDS）中1994年7月1日至1997年6月30日期间接受肾移植的33479名患者进行回顾性注册研究。评估了与以骨折（所有原因）为主要出院诊断的住院情况之间的关联。
结果：肾移植受者骨折的校正发生率比为4.59（95%置信区间为3.29 - 6.31）。在多变量分析中，已有骨折的受者，以及白人、女性、受者体重处于较低四分位数（<95.9 kg）、因糖尿病导致终末期肾病以及移植前透析时间延长的受者，在移植后因骨折住院的风险增加。在Cox回归分析中，因髋部骨折住院的受者全因生存率降低（死亡风险比为1.60，95%置信区间为1.13 - 2.26）。
结论：在移植后的早期过程中（
PURPOSE: To investigate the incidence, risk factors, and associated mortality of fractures in renal transplant recipients.METHODS: Retrospective registry study of 33,479 patients in the United States Renal Data System (USRDS) who received kidney transplants between I July 1994 and 30 June 1997. Associations with hospitalizations for a primary discharge diagnosis of fractures (all causes) were assessed.RESULTS: Renal transplant recipients had an adjusted incidence ratio for fractures of 4.59 (95% confidence interval 3.29 to 6.31). In multivariate analysis, recipients with prevalent fractures, as well as recipients who were Caucasian, women, in the lower quartiles of recipient weight (< 95.9 kg), had end stage renal disease caused by diabetes, and had prolonged pretransplant dialysis were at increased risk for hospitalization because of fractures after transplantation. Recipients hospitalized for hip fracture,, had decreased all-cause survival (hazard ratio for mortality 1.60, 95% CI 1.13 to 2.26) in Cox Regression analysis,CONCLUSIONS: In the early post,transplant course (