Hepatitis B virus X protein: TRIMming antiviral defences in hepatocytes.
Hepatitis B virus X protein: TRIMming antiviral defences in hepatocytes.
复制标题
乙型肝炎病毒 X 蛋白：修剪肝细胞中的抗病毒防御。
DOI：
10.1136/gutjnl-2017-314013
复制
发表时间：
2018
期刊：
影响因子：
24.5
通讯作者：
Thomas,Emmanuel
中科院分区：
文献类型：
--
作者：
Thomas,Emmanuel
人类和病毒经过数千年的共同进化；然而，很少有病毒能够表现为慢性感染，大多数病毒在急性病程后被清除。因此，人类物种的成功依赖于能够击退大多数病毒病原体的功能免疫系统。乙型肝炎病毒是最成功地在人类中建立慢性感染的病毒之一，目前全世界有超过3亿人感染，超过20亿人感染了这种病毒。1这些数字突显了乙肝病毒阻碍人类免疫系统和建立慢性感染的巨大能力。在这一期的《肠道》杂志上，Lim等人提供了证据，证明了一种新的机制，通过这种机制，乙肝病毒能够建立和维持慢性感染。他们特别研究了神秘的HBx蛋白3在调节TRIM22中的作用，TRIM22是一种越来越与先天抗病毒反应相关的蛋白质。4 5先前的研究表明，HBx是一种病毒编码的蛋白质，在其生命周期中扮演着不寻常的角色，可以与迈阿密大学米勒医学院希夫肝病中心的Emmanuel Thomas博士通信，迈阿密，FL 33136，美国；ethomas1@med。迈阿密。2024年6月21日，EDU在谷歌索引器上。受版权保护。Http://gut.BMJ。COM/
Humans and viruses have coevolved over thousands of years; however, very few viruses are able to manifest as chronic infections with most being cleared after an acute course. Consequently, success of the human species has relied on a functional immune system that is capable of fighting off most viral pathogens. The heptatitis B virus (HBV) is one of the most successful viruses to establish chronic infection in man with over 300 million individuals currently infected worldwide and over2 billion humans having been infected by this virus. 1 These numbers underscore the tremendous ability of HBV to thwart the human immune system and establish chronic infection. In this issue of Gut, Lim et al 2 have provided evidence for a new mechanism through which HBV is able to establish and maintain chronic infection. They specifically examine the role of the enigmatic HBx protein 3 in the regulation of TRIM22, a protein that has increasingly become associated with innate antiviral responses. 4 5 Previous studies have demonstrated that HBx, a virally encoded protein that plays unusual roles in its life cycle, can correspondence to Dr Emmanuel Thomas, Schiff Center for Liver Diseases, University of Miami Miller School of Medicine, Miami, FL 33136, USA; EThomas1@ med. miami. edu on June 21, 2024 at Google Indexer. Protected by copyright. http://gut. bmj. com/