Implications of circulating Meteorin-like (Metrnl) level in human subjects with type 2 diabetes
Implications of circulating Meteorin-like (Metrnl) level in human subjects with type 2 diabetes
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DOI：
10.1016/j.diabres.2017.11.031
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发表时间：
2018-02-01
影响因子：
5.1
通讯作者：
Choi, Kyung Mook
中科院分区：
文献类型：
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作者：
Chung, Hye Soo;Hwang, Soon Young;Choi, Kyung Mook
目的：镍纹蛋白样蛋白（Metrnl）是最近发现的一种新的由运动和冷暴露诱导的脂肪肌细胞因子。Metrnl在肥胖/糖尿病小鼠中改善葡萄糖耐量，增加全身能量消耗，诱导白色脂肪布朗宁，并促进抗炎基因程序。然而，Metrnl与糖尿病和心脏代谢风险变量在人类中的关系尚未探讨。在800名受试者中（400名2型糖尿病患者和400名非糖尿病患者），用酶联免疫吸附测定法测量Metrnl浓度，并研究Metrnl水平与人体测量参数、生活方式因素、身体组成值、结果：糖尿病患者的Metrnl浓度显著高于非糖尿病患者[中位数（四分位数间距）;糖尿病：1219.9（1020.6，1535.6），非糖尿病：1131.2（993.1，1313.6）pg/ml，P
Aims: Meteorin-like (Metrnl) was recently identified as a novel adipomyokine induced by exercise and cold exposure. Metrnl improves glucose tolerance, increases systemic energy expenditure, induces white adipose browning, and promotes anti-inflammatory gene programs in obese/diabetic mice. However, the relationship of Metrnl with diabetes and cardiometabolic risk variables in humans has not been explored.Methods: In 800 subjects (400 patients with type 2 diabetes and 400 non-diabetes), Metrnl concentration was measured with an enzyme-linked immunosorbent assay, and the correlations of Metrnl level with anthropometric parameters, lifestyle factors, body composition values, and laboratory measurements were assessed.Results: Metrnl concentration was significantly higher in patients with diabetes than in those without diabetes [median (inter-quartile range); diabetes: 1219.9 (1020.6, 1535.6), non-diabetes: 1131.2 (993.1, 1313.6) pg/ml, P