Exacerbation of inflammatory demyelinating polyneuropathy after bone marrow transplantation.
Exacerbation of inflammatory demyelinating polyneuropathy after bone marrow transplantation.
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DOI：
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发表时间：
1991
影响因子：
4.8
通讯作者：
H. Openshaw;D. Hinton;N. Slatkin;P. Bierman;F. Hoffman;D. Snyder
中科院分区：
文献类型：
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作者：
H. Openshaw;D. Hinton;N. Slatkin;P. Bierman;F. Hoffman;D. Snyder
两名血液恶性肿瘤和静止期炎性脱髓鞘性多发性神经病患者在骨髓移植时发生了严重的多发性神经病恶化。尽管接受了免疫抑制剂、血浆置换和大剂量免疫球蛋白治疗，但两例患者的临床病程仍在进展。多发性神经病导致四肢瘫痪，导致患者在移植后175天和48天死亡。在第一例中，尸检取样的多个周围神经的切片显示显著的脱髓鞘，伴有巨噬细胞和淋巴细胞的大量浸润。免疫组织化学研究表明，大多数的淋巴细胞的CD 8+，细胞毒性/抑制细胞类和许旺细胞表达II类（HLA-DR）抗原。本报告提示骨髓移植可加重炎性脱髓鞘性多发性神经病。
Two patients with hematologic malignancy and quiescent inflammatory demyelinating polyneuropathy developed severe exacerbations of polyneuropathy at the time of bone marrow transplantation. The clinical course in both patients was progressive despite therapy with immuno-suppressive agents, plasmapheresis, and high dose immunoglobulin. The polyneuropathy resulted in quadriplegia which contributed to the patients' deaths 175 and 48 days after transplantation. Sections of multiple peripheral nerves sampled post mortem in the first case revealed prominent demyelination with heavy infiltration of macrophages and lymphocytes. Immunohistochemical studies demonstrated that most of the lymphocytes were of the CD8+, cytotoxic/suppressor cell class and that many of the Schwann cells expressed class II (HLA-DR) antigen. This report suggests that bone marrow transplantation can exacerbate inflammatory demyelinating polyneuropathy.