Early Mortality Following Intracerebral Infection with the Oshima Strain of Tick-Borne Encephalitis Virus in a Mouse Model
Early Mortality Following Intracerebral Infection with the Oshima Strain of Tick-Borne Encephalitis Virus in a Mouse Model
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DOI：
10.1292/jvms.09-0258
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发表时间：
2010-04-01
影响因子：
1.2
通讯作者：
Koike, Satoshi
中科院分区：
文献类型：
--
作者：
Hayasaka, Daisuke;Nagata, Noriyo;Koike, Satoshi
蜱传脑炎病毒 (TBEV) 是一种人畜共患病病原体，可引起人类急性中枢神经系统 (CNS) 疾病。在这项研究中，我们在小鼠模型中检查了 TBEV 大岛株脑内感染后的致病过程。脑内感染导致剂量依赖性死亡率，所有小鼠在 10(2) PFU 或更多病毒攻击后 10 天内死亡。在整个中枢神经系统中观察到神经元急性坏死和广泛的炎症。因此，我们得出结论，脑内感染后的死亡是由直接的中枢神经系统病理学引起的。
Tick-borne encephalitis virus (TBEV) is a zoonotic agent that causes acute central nervous system (CNS) disease in humans. In this study, we examined the pathogenic process following intracerebral infection with the Oshima strain of TBEV in a mouse model. Intracerebral infection resulted in dose-dependent mortality, and all mice died following challenge with 10(2) PFU or more of the virus within 10 days. Acutely necrotic neurons and widespread inflammation were observed throughout the CNS. We therefore conclude that mortality following intracerebral infection results from a direct CNS pathology.