Modulation of Calcium Currents by Adenosine Receptors on Mammalian Sympathetic Neurons
Modulation of Calcium Currents by Adenosine Receptors on Mammalian Sympathetic Neurons
复制标题
腺苷受体对哺乳动物交感神经元钙电流的调节
DOI：
--
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
D. McAfee
中科院分区：
文献类型：
--
作者：
B. Henon;D. McAfee
电压依赖性 Ca 电流的调节是调节神经元活动的强大机制。现在已经证明几种神经递质具有这种能力。 GABA、去甲肾上腺素和血清素抑制背根神经节中的神经元 Ca 电导 [1]。去甲肾上腺素还抑制大鼠颈上神经节节后神经元中的 Ca2+电流[2]。尽管尚不清楚腺苷是否具有神经递质的资格，但我们现在已经证明，腺苷通过激活这些节后神经元胞体上的腺苷受体来抑制电压依赖性 Ca 电流 [3]。
The modulation of voltage-dependent Ca currents is a powerful mechanism for the regulation of neuronal activity. Several neurotransmitters have now been shown to have this capability. GABA, noradrenalin, and serotonin inhibit neuronal Ca conductances in the dorsal root ganglion [1]. Noradrenalin also inhibits Ca currents in the postganglionic neurons of the rat superior cervical ganglion [2]. Although it is not clear that adenosine qualifies as a neurotransmitter, we have now shown that adenosine inhibits voltagedependent Ca currents by activation of adenosine receptors on the somata of these postganglionic neurons [3].