The yeast protein interaction network evolves rapidly and contains few redundant duplicate genes
The yeast protein interaction network evolves rapidly and contains few redundant duplicate genes
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DOI：
10.1093/oxfordjournals.molbev.a003913
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发表时间：
2001-07-01
影响因子：
10.7
通讯作者：
Wagner, A
中科院分区：
文献类型：
--
作者：
Wagner, A
本文分析了酵母（Saccharomyces cerevisiae）蛋白相互作用网络的结构和进化。网络被看作是一个图，它的节点对应于蛋白质。如果两个蛋白质相互作用，它们就通过一条边连接起来。该网络类似于一个随机图，因为它由许多小子网（相互作用但不与任何其他蛋白质相互作用的蛋白质组）和一个大的连接子网组成，其中包含所有相互作用蛋白质的一半以上。每个蛋白质的相互作用次数似乎遵循幂律分布。在一次复制后大约200 Myr内，重复基因的产物几乎同样有可能(1)具有共同的蛋白质相互作用伙伴，(2)与从网络中随机选择的两个蛋白质成为同一子网络的一部分。这表明冗余交互伙伴的持久性是例外，而不是规则。基因复制后，相互作用丢失的可能性超过2.2 X 10(-3)/Myr。据估计，新的相互作用以大约小三个数量级的速度发展。每300迈尔，多达一半的相互作用可能被新的相互作用所取代。
In this paper, the structure and evolution of the protein interaction network of the yeast Saccharomyces cerevisiae is analyzed. The network is viewed as a graph whose nodes correspond to proteins Two proteins are connected by an edge if they interact. The network resembles a random graph in that it consists of many small subnets (groups of proteins that interact with each ether but do not interact with any other protein) and one large connected subnet comprising more than half of all interacting proteins. The number of interactions per protein appears to follow a power law distribution. Within approximately 200 Myr after a duplication, the products of duplicate genes become almost equally likely to (1) have common protein interaction partners and (2) be part of the same subnetwork as two proteins chosen at random from within the network. This indicates that the persistence of redundant interaction partners is the exception rather than the rule. After gene duplication, the likelihood that an interaction gets lost exceeds 2.2 X 10(-3)/Myr. New interactions are estimated to evolve at a rate that is approximately three orders of magnitude smaller. Every 300 Myr, as many as half of all interactions may be replaced by new interactions.