CMV retinitis after allogeneic bone marrow transplantation: a report of five cases.
CMV retinitis after allogeneic bone marrow transplantation: a report of five cases.
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DOI：
10.1034/j.1399-3062.2002.01018.x
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发表时间：
2002-06-01
期刊：
影响因子：
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通讯作者：
Ljungman, P
中科院分区：
文献类型：
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作者：
Larsson, Kajsa;Lonnqvist, B;Ljungman, P
1994年至1999年，在Huddinge大学医院记录了4例异基因造血干细胞移植（SCT）后发生巨细胞病毒（CMV）视网膜炎（CMVR）的病例。在1994年之前，只有一例记录在案。所有5例患者均因恶性疾病接受移植，2例为同胞供体，3例为匹配的无关供体。尽管对CMV视网膜炎进行了充分的抗病毒治疗，但结果是三名患者几乎完全单侧失明。然而，这种并发症似乎变得更加常见，因为我们开始做更多匹配的非亲缘供体移植，这导致了更明显的T细胞缺陷和延迟的免疫重建。我们的结论是巨细胞病毒视网膜炎是一种罕见的，但重要的并发症异基因造血干细胞移植。
Four cases of cytomegalovirus (CMV) retinitis (CMVR) after allogeneic blood stem cell transplant (SCT) were documented in Huddinge University Hospital between 1994 and 1999. Prior to 1994, only one case was documented. All five patients were transplanted due to malignant disease, two with sibling donors and three with matched unrelated donors. Despite adequate antiviral treatment against CMV retinitis, the result has been almost total unilateral blindness in three patients. However rare, the complication seems to have become more common since we began doing more matched unrelated donor transplants, which leads to a more pronounced T-cell defect and to a delayed immune reconstitution compared to sibling transplants. We conclude that CMV retinitis is a rare but important complication to allogeneic blood stem cell transplantation.