Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4
Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4
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DOI：
10.1073/pnas.0702257104
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发表时间：
2007-05-08
影响因子：
11.1
通讯作者：
Ottenhoff, Tom H. M.
中科院分区：
文献类型：
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作者：
Joosten, Simone A.;van Meijgaarden, Krista E.;Ottenhoff, Tom H. M.
调节性T细胞(Treg)由多个亚群组成，在控制免疫和炎症方面起着重要作用。然而，各种不同的Treg亚群的诱导和作用模式仍然不清楚，特别是在人类中。在这里，我们描述了一个人CD8(+)淋巴细胞激活基因-3(LAG-3)(+)CD25(+)FoxP3(+)Treg亚群，它通过分泌CC趋化因子配体4(CCL4)部分抑制T细胞，通过干扰T细胞受体信号来抑制T细胞的激活。CD8(+)Tregs在体内启动的供者体内通过抗原扩增，并可在感染病原菌的人体组织中检测到。因此，CD8(+)LAG-3(+)CD25(+)FoxP3(+)CCl4(+)Treg亚群可能在包括传染病在内的人体免疫调节中发挥作用。
Regulatory T cells (Treg) comprise multiple subsets and are important in controlling immunity and inflammation. However, the induction and mode of action of the various distinct Treg subsets remain ill defined, particularly in humans. Here, we describe a human CD8(+)lymphocyte activation gene-3 (LAG-3)(+)CD25(+)FoxP3(+) Treg subset, which suppresses T cells partly through the secretion of CC chemokine ligand 4 (CCL4), which can inhibit T cell activation by interfering with T cell receptor signaling. CD8(+) Tregs are expanded by antigen in in vivo-primed donors, and can be detected in pathogeri infected human tissue. This CD8(+)LAG-3(+)CD25(+)FoxP3(+)CCL4(+) Treg subset thus may play a role in immunoregulation in humans, including infectious diseases.