Evaluating multicenter DTI data in Huntington's disease on site specific effects: An ex post facto approach.
Evaluating multicenter DTI data in Huntington's disease on site specific effects: An ex post facto approach.
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DOI：
10.1016/j.nicl.2012.12.005
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发表时间：
2013
影响因子：
4.2
通讯作者：
Suessmuth, Sigurd D.
中科院分区：
文献类型：
--
作者：
Mueller, Hans-Peter;Groen, Georg;Sprengelmeyer, Reiner;Kassubek, Jan;Ludolph, Albert C.;Hobbs, Nicola;Cole, James;Roos, Raymund A. C.;Duerr, Alexandra;Tabrizi, Sarah J.;Landwehrmeyer, G. Bernhard;Suessmuth, Sigurd D.
评估在多中心研究过程中获取的MRI数据的平均弥散张量成像（DTI）指标的可行性。六十一早期阶段的亨廷顿病患者和40名健康对照进行了研究，使用四种不同的MR扫描仪在四个欧洲网站的收购协议尽可能接近给定的标准协议。通过基于感兴趣区域（ROI）的各中心变异系数（CV）统计比较，以及通过检测患者和对照组之间平均各向异性分数（FA）值的显著组间差异，定量评价了对不同部位采集的数据取平均值的可能性和可行性。此外，使用FA图进行了基于全脑的组间统计比较。先验定义的ROI中CV和FA值的事后统计学评价显示，研究中心之间没有高于偶然性的差异，表明数据没有因研究中心特定因素而出现系统性偏倚。从不同研究中心和不同MR扫描仪类型获得的DTI数据中平均FA图似乎没有系统性偏倚。提供了一种合适的方法来测试合并多中心DTI数据的可能性，以允许对DTI衍生的指标进行平均，从而在更大的范围内区分患者和健康对照。评价多中心DTI数据汇集先决条件的替代程序。结论：MRI技术可作为HD多中心MRI DTI临床试验的参考。HD和对照组之间的FFA差异与单中心报告一致。
Assessment of the feasibility to average diffusion tensor imaging (DTI) metrics of MRI data acquired in the course of a multicenter study. Sixty-one early stage Huntington's disease patients and forty healthy controls were studied using four different MR scanners at four European sites with acquisition protocols as close as possible to a given standard protocol. The potential and feasibility of averaging data acquired at different sites was evaluated quantitatively by region-of-interest (ROI) based statistical comparisons of coefficients of variation (CV) across centers, as well as by testing for significant group-by-center differences on averaged fractional anisotropy (FA) values between patients and controls. In addition, a whole-brain based statistical between-group comparison was performed using FA maps. The ex post facto statistical evaluation of CV and FA-values in a priori defined ROIs showed no differences between sites above chance indicating that data were not systematically biased by center specific factors. Averaging FA-maps from DTI data acquired at different study sites and different MR scanner types does not appear to be systematically biased. A suitable recipe for testing on the possibility to pool multicenter DTI data is provided to permit averaging of DTI-derived metrics to differentiate patients from healthy controls at a larger scale. ► Alternative procedure to evaluate prerequisites for multicenter DTI data pooling. ► Procedure may serve as reference for future multicenter MRI-DTI trials in HD. ► FA differences between HD and controls consistent with single center reports.
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影响因子：
5.7
作者：
Vollmar, Christian;O'Muircheartaigh, Jonathan;Barker, Gareth J.;Symms, Mark R.;Thompson, Pamela;Kumari, Veena;Duncan, John S.;Richardson, Mark P.;Koepp, Matthias J.
通讯作者：
Koepp, Matthias J.
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
影响因子：
3.5
作者：
Fox, R. J.;Sakaie, K.;Fisher, E.
通讯作者：
Fisher, E.
影响因子：
2.3
作者：
Teipel, Stefan J.;Reuter, Sigrid;Hampel, Harald
通讯作者：
Hampel, Harald
影响因子：
--
作者：
Mueller, Hans-Peter;Unrath, Alexander;Kassubek, Jan
通讯作者：
Kassubek, Jan