Development of a deep-red fluorescent glucose-conjugated bioprobe for in vivo tumor targeting
Development of a deep-red fluorescent glucose-conjugated bioprobe for in vivo tumor targeting
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开发用于体内肿瘤靶向的深红色荧光葡萄糖共轭生物探针
DOI：
10.1039/c9cc07363a
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发表时间：
2020-01-21
影响因子：
4.9
通讯作者：
Li, Enmin
中科院分区：
文献类型：
--
作者：
Cheng, Yinwei;Shabir, Ghulam;Li, Enmin
合成了一种C1型d-葡萄糖标记的荧光探针Glu-1-O-DCSN，在DMSO溶液中，该荧光探针在685 nm处发射深红色光，Stokes位移达150 nm。在体外活细胞成像中，Glu-1-O-DCSN表现出与d-葡萄糖相似的竞争性摄取行为，并选择性地位于线粒体中。此外，Glu-1-O-DCSN成功地用于体内高代谢肿瘤靶向。
A C1-type d-glucose-conjugated fluorescent probe Glu-1-O-DCSN was synthesized and showed deep-red emission at 685 nm with a Stokes shift of up to 150 nm in DMSO. In in vitro live cell imaging, Glu-1-O-DCSN exhibited similar and competitive uptake behaviours to d-glucose and was selectively located in mitochondria. Furthermore, Glu-1-O-DCSN was successfully employed for in vivo hypermetabolic tumor targeting.