Bilateral acute corneal calcification.
Bilateral acute corneal calcification.
复制标题
双侧角膜急性钙化。
DOI：
10.1016/s0161-6420(85)34000-9
复制
发表时间：
1985
期刊：
影响因子：
13.7
通讯作者：
Leibowitz,HM
中科院分区：
文献类型：
--
作者：
Freddo,TF;Leibowitz,HM
一名38岁男性，患有脆性、青少年型糖尿病和双侧严重干眼伴复发性角膜溃疡，在24小时内双侧角膜出现非典型带状钙化。血清钙、磷酸盐和二氧化碳水平均在正常范围内。患者轻度尿毒症，但未发生肾衰竭。当EDTA螯合未能清除沉积物时，在双眼中进行部分角膜切除术，并通过光学和电子显微镜检查标本，包括能量色散X射线分析。显微镜检查显示非典型钙化性角膜病变，既不涉及鲍曼层，也不涉及最浅的基质层。沉积物局限于前基质中的深层，电子显微镜下由细胞外结晶聚集体组成。这些聚集体的能量色散X射线分析证实了钙和磷酸盐的存在。角膜干燥似乎是这些沉积物快速形成的主要促成因素。
A 38-year-old man with brittle, juvenile onset diabetes mellitus and bilateral severe dry eyes with recurrent corneal ulcers developed atypical band-shaped calcifications of both corneas during a 24-hour period. Serum calcium, phosphate, and carbon dioxide levels all were within normal limits. The patient was mildly uremic but was not in renal failure. When EDTA chelation failed to clear the deposits, partial keratectomies were performed in both eyes and the specimens were examined by light and electron microscopy, including energy dispersive x-ray analysis. Microscopic studies revealed an atypical calcific keratopathy which involved neither Bowman's layer nor the most superficial stromal lamellae. The deposits were confined to deeper lamellae in the anterior stroma and by electron microscopy were composed of extracellular crystalline aggregates. Energy dispersive x-ray analysis of these aggregates confirmed the presence of calcium and phosphate. Corneal dessication appeared to be a major contributing factor in the rapid formation of these deposits.