Impaired probabilistic reversal learning in youths with mood and anxiety disorders.
Impaired probabilistic reversal learning in youths with mood and anxiety disorders.
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DOI：
10.1017/s0033291709991462
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发表时间：
2010-07
影响因子：
6.9
通讯作者：
Leibenluft, E.
中科院分区：
文献类型：
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作者：
Dickstein, D. P.;Finger, E. C.;Brotman, M. A.;Rich, B. A.;Pine, D. S.;Blair, J. R.;Leibenluft, E.
从情感神经科学的角度来看，我们对精神疾病的理解可以通过探索情绪过程的神经心理学测试范式来推进。反转学习就是这样一个过程，受试者必须首先通过试错获得刺激/奖赏和刺激/惩罚联想，然后再逆转它们。我们试图通过现在将双相情感障碍(BD)青年与患有严重情绪调节障碍(SMD)、严重抑郁障碍(MDD)、焦虑(ANX)和健康对照的青年进行比较，来确定先前证明的双相情感障碍(BD)青年中反向学习障碍的特异性。我们对165名7-17岁的儿童受试者进行了概率反应逆转(PRR)任务，包括BD(n=35)、SMD(n=35)、ANX(n=42)、MDD(n=18)和正常对照组(n=35)。我们的初步分析比较了年龄、性别和智商匹配的所有五组的PRR表现。与典型的发育正常对照相比，BD青少年的概率反转学习受到损害，MDD患者有下降趋势(p=0.07)。我们的结果表明，患有BD的年轻人和可能患有MDD的年轻人存在反向学习缺陷。需要进一步的工作来阐明这种行为缺陷背后的神经机制的特殊性。
From an affective neuroscience perspective, our understanding of psychiatric illness may be advanced by neuropsychological test paradigms probing emotional processes. Reversal learning is one such process, whereby subjects must first acquire stimulus/reward and stimulus/punishment associations through trial and error and then reverse them. We sought to determine the specificity of previously demonstrated reversal learning impairments in youths with bipolar disorder (BD) by now comparing BD youths to those with severe mood dysregulation (SMD), major depressive disorder (MDD), anxiety (ANX), and healthy controls. We administered the probabilistic response reversal (PRR) task to 165 pediatric participants aged 7–17 years with BD (n = 35), SMD (n = 35), ANX (n = 42), MDD (n = 18) and normal controls (NC; n = 35). Our primary analysis compared PRR performance across all five groups matched for age, sex and IQ. Compared to typically developing controls, probabilistic reversal learning was impaired in BD youths, with a trend in those with MDD (p = 0.07). Our results suggest that reversal learning deficits are present in youths with BD and possibly those with MDD. Further work is necessary to elucidate the specificity of neural mechanisms underlying such behavioral deficits.