DECREASE OF SYNAPTIC PLASTICITY ASSOCIATED WITH ALTERATION OF INFORMATION FLOW IN A RAT MODEL OF VASCULAR DEMENTIA
DECREASE OF SYNAPTIC PLASTICITY ASSOCIATED WITH ALTERATION OF INFORMATION FLOW IN A RAT MODEL OF VASCULAR DEMENTIA
复制标题
血管性痴呆大鼠模型中与信息流改变相关的突触可塑性下降
DOI：
10.1016/j.neuroscience.2011.12.050
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发表时间：
2012-03-29
期刊：
影响因子：
3.3
通讯作者：
Zhang, T.
中科院分区：
文献类型：
--
作者：
Xu, X.;Li, Z.;Zhang, T.
本研究旨在探讨神经信息流方向指数（NIF）是否可用于表征海马CA 3-CA 1通路的突触可塑性，并评估哪种振荡节律与血管性痴呆（VD）引起的认知障碍相关。将大鼠随机分为对照组和VD组。VD动物模型采用二血管闭塞法（2 VO）。使用Morris水迷宫（MWM）测量行为。在行为测试后记录来自CA 3和CA 1的局部场电位（LFP），随后记录相同CA 3-CA 1通路的长时程增强（LTP）。利用一般部分定向相干（gPDC）方法来确定在五个频带上CA 3和CA 1之间的NIF的方向性，这五个频带是δ、θ、α、β和γ。结果表明，VD组的逃避潜伏期明显延长，而两组的游泳速度在整个测试过程中保持不变。此外，与正常状态相比，VD状态下CA 3和CA 1区域之间的相位同步值在θ、α、β和γ带中降低。VD大鼠在上述4个频段的耦合方向指数明显降低，而在同一频段内，CA 3驱动CA 1的强度明显降低。有趣的是，VD组的LTP显著降低，这与LFP的发现一致。这些数据表明，在这些生理振荡节律的NIF的方向性指数可以被用来作为VD状态下海马CA 3-CA 1通路中的突触可塑性的量度。对VD状态下NIF方向与突触可塑性关系的可能机制进行了讨论。(C)2012年IBRO。由爱思唯尔有限公司出版。保留所有权利。
This investigation examined whether the directional index of neural information flow (NIF) could be employed to characterize the synaptic plasticity in the CA3-CA1 pathway of the hippocampus and assessed which oscillatory rhythm was associated with cognitive impairments induced by vascular dementia (VD). Rats were randomly divided into control and VD groups. The animal model of VD used the two-vessel occlusion (2VO) method. Behavior was measured using the Morris water maze (MWM). Local field potentials (LFPs) from CA3 and CA1 were recorded after behavioral tests, followed by recording long-term potentiation (LTP) of the same CA3-CA1 pathway. General partial directed coherence (gPDC) approach was utilized to determine the directionality of NIF between CA3 and CA1 over five frequency bands, which were delta, theta, alpha, beta, and gamma. The results showed that the escape latencies were significantly prolonged in the VD group, whereas the swimming speeds of these two groups remained constant throughout testing. Moreover, the phase synchronization values between CA3 and CA1 regions were reduced in theta, alpha, beta, and gamma bands in the VD state compared to that in the normal state. The coupling directional index was considerably decreased in the previously given four frequency bands in VD rats, whereas the strength of CA3 driving CA1 was significantly reduced in the same frequency bands. Interestingly, LTP was significantly decreased in the VD group, which was consistent with the LFPs findings. The data suggest that the directionality index of NIF in these physiological oscillatory rhythms could be used as a measure of synaptic plasticity in the hippocampal CA3-CA1 pathway in VD states. The potential mechanism of the relationship between NIF direction and synaptic plasticity in VD state was discussed. (C) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.