NON-RANDOM ASSOCIATION BETWEEN ELECTROMORPHS AND INVERSION CHROMOSOMES IN FINITE POPULATIONS
NON-RANDOM ASSOCIATION BETWEEN ELECTROMORPHS AND INVERSION CHROMOSOMES IN FINITE POPULATIONS
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DOI：
10.1017/s001667230001394x
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发表时间：
1980-01-01
影响因子：
1.5
通讯作者：
LI, WH
中科院分区：
文献类型：
--
作者：
NEI, M;LI, WH
为了确定倒位染色体与电形态之间的非随机关联的可能程度，我们对非随机关联的进化变化进行了确定性和随机研究。非随机关联定义为一个给定等位基因在倒位染色体和非倒位染色体之间的频率差异。反转染色体被认为是受选择的，但电形态是选择性中性的，并且允许在反转染色体和非反转染色体之间以低频率发生重组。确定性研究表明，在反转染色体的各种选择方案中，非随机关联衰减的速率等于每一代的重组值。如果重组值的数量级为10-5 .apprx。10比4，非随机关联需要很长时间才能消失。随机研究表明，在有限种群中，随机遗传漂变会产生反转和电态的非随机关联，而非随机关联的标准误差往往大于平均值。研究了在有限种群中反转染色体和非反转染色体的电形态频率相等所需的时间，以及引入的初始反转中存在的等位基因在反转染色体种群中保持单态的概率。电形态和倒位之间的非随机关联的数据对于研究蛋白质多态性的维持可能不是很有用。在电形态与倒位染色体的关联研究中，非随机关联或Yule关联系数比通常的连锁不平衡度量或相关系数具有更好的性能。讨论了本研究对某些实验结果的启示。
To determine the probable magnitude of non-random association between inversion chromosomes and electromorphs, deterministic and stochastic studies were conducted on the evolutionary change of non-random association, which is defined as the difference in the frequency of a given allele between inversion and non-inversion chromosomes. Inversion chromosomes are assumed to be subject to selection but electromorphs are selectively neutral, and recombination is allowed to occur between inversion and non-inversion chromosomes with a low frequency. The deterministic study showed that in a variety of selective schemes for inversion chromosomes the non-random association decays at a rate equal to the recombination value in every generation. If the recombination value is of the order of 10-5 .apprx. 10-4, it would take a long time for the non-random association to disappear. The stochastic study indicated that random genetic drift generates non-random association of inversions and electromorphs in finite populations and the standard error of non-random association often becomes larger than the mean. The time required for the electromorph frequencies in the inversion and noninversion chromosomes to become equal in a finite population and the probability that the population of inversion chromosomes remains monomorphic for the allele which existed in the initial inversion introduced are studied. Data on the non-random association between electromorphs and inversions are probably not very informative for the study of the maintenance of protein polymorphism. In the study of association between electromorphs and inversion chromosomes, non-random association or Yule''s coefficient of association has a better property than the usual linkage disequilibrium measure or correlation coefficient. Implications of this study on some experimental observations are discussed.