Nonoxidative ethanol metabolism: formation of fatty acid ethyl esters by cholesterol esterase.
Nonoxidative ethanol metabolism: formation of fatty acid ethyl esters by cholesterol esterase.
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非氧化乙醇代谢：胆固醇酯酶形成脂肪酸乙酯。
DOI：
10.1073/pnas.79.13.3954
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发表时间：
1982
影响因子：
11.1
通讯作者：
Lange,LG
中科院分区：
文献类型：
--
作者：
Lange,LG
最近发现的乙醇心肌代谢产物-脂肪酸乙酯-表明，一些与酒精诱导的心肌疾病相关的病理生理紊乱可能是心肌乙醇代谢产物的结果。在脂肪酸乙酯的形成中，脂肪酸部分的供体已被鉴定为非酯化脂肪酸。脂肪酸与乙醇的酯化作用是由胆固醇酯酶（甾醇酯酰基水解酶，EC 3.1.1.13）介导的，这一发现确定了酶的单一非氧化乙醇代谢。还提出了乙醇摄入对动脉粥样硬化形成的保护作用的潜在基础，因为脂肪酸乙酯抑制由胰腺胆固醇酯酶和肝和主动脉微粒体脂肪酰基-CoA：胆固醇O-酰基转移酶催化的胆固醇酯化（EC 2.3.1.26）。
The recent identification of myocardial metabolites of ethanol--fatty acid ethyl esters--suggests that some of the pathophysiological derangements associated with alcohol-induced heart muscle disease may be a consequence of products of myocardial ethanol metabolism. The donor of the fatty acid moiety in the formation of fatty acid ethyl esters has been identified as nonesterified fatty acid. Fatty acid esterification with ethanol is shown to be mediated by cholesterol esterase (sterol-ester acylhydrolase, EC 3.1.1.13), a finding that identifies a singular nonoxidative ethanol metabolism by an enzyme. A potential basis for the protective effect of ethanol ingestion on atherogenesis is also suggested because fatty acid ethyl esters inhibit cholesterol esterification catalyzed by pancreatic cholesterol esterase and hepatic and aortic microsomal fatty acyl-CoA:cholesterol O-acyltransferase (EC 2.3.1.26).