Investigating patterns of neural response associated with childhood abuse v. childhood neglect.
Investigating patterns of neural response associated with childhood abuse v. childhood neglect.
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研究与儿童虐待和儿童忽视相关的神经反应模式。
DOI：
10.1017/s003329171900134x
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发表时间：
2020
影响因子：
6.9
通讯作者：
McCrory,Eamon
中科院分区：
文献类型：
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作者：
Puetz,VanessaBianca;Viding,Essi;Gerin,MattiaIndi;Pingault,Jean-Baptiste;Sethi,Arjun;Knodt,AnnchenR;Radtke,SpenserR;Brigidi,BartD;Hariri,AhmadR;McCrory,Eamon
背景儿童虐待与不良心理健康结果和大脑功能变化的风险增加密切相关。作者调查了童年遭受虐待（例如身体、情感和性虐待）和忽视（身体和情感剥夺）的经历是否与对威胁的神经反应存在差异相关。方法参与者从现有研究中抽取，并根据童年虐待经历的自我报告分配到四个组中的一组：有童年虐待经历的个体（n = 70）；有童年虐待经历的个体（n = 70）；有童年被忽视经历的个体（n = 87）；具有童年虐待和忽视综合经历的个人（n = 50）；和未受虐待的个体 (n = 207) 在性别、年龄、智商、精神病理学和社会经济地位方面进行倾向评分匹配 (PSM)。比较各组对发出威胁信号的面部线索的神经反应，从而分离出与特定形式的虐待经历相关的差异效应。结果脑成像分析表明，虽然童年虐待与腹侧杏仁核局部威胁反应性增强有关，但忽视经历与支持复杂社会和认知处理的分布式皮质额顶叶网络以及背侧杏仁核的反应性增强有关。出乎意料的是，虐待和忽视的综合经历与几个高阶皮质区域以及杏仁核的低激活有关。结论不同形式的儿童虐待对神经威胁反应产生不同的影响：虽然虐待的影响更加集中，但忽视和虐待的综合经历的影响更加分散。这些发现有助于了解儿童虐待后的精神结局范围，并对干预具有影响。
BackgroundChildhood maltreatment is robustly associated with increased risk of poor mental health outcome and changes in brain function. The authors investigated whether childhood experience of abuse (e.g. physical, emotional and sexual abuse) and neglect (physical and emotional deprivation) was differentially associated with neural reactivity to threat.MethodsParticipants were drawn from an existing study and allocated to one of four groups based on self-report of childhood maltreatment experience: individuals with childhood abuse experiences (n = 70); individuals with childhood neglect experiences (n = 87); individuals with combined experience of childhood abuse and neglect (n = 50); and non-maltreated individuals (n = 207) propensity score matched (PSM) on gender, age, IQ, psychopathology and SES. Neural reactivity to facial cues signalling threat was compared across groups, allowing the differential effects associated with particular forms of maltreatment experience to be isolated.ResultsBrain imaging analyses indicated that while childhood abuse was associated with heightened localised threat reactivity in ventral amygdala, experiences of neglect were associated with heightened reactivity in a distributed cortical fronto-parietal network supporting complex social and cognitive processing as well as in the dorsal amygdala. Unexpectedly, combined experiences of abuse and neglect were associated with hypo-activation in several higher-order cortical regions as well as the amygdala.ConclusionsDifferent forms of childhood maltreatment exert differential effects in neural threat reactivity: while the effects of abuse are more focal, the effects of neglect and combined experiences of abuse are more distributed. These findings are relevant for understanding the range of psychiatric outcomes following childhood maltreatment and have implications for intervention.