DNA mismatch repair and the DNA damage response.
DNA mismatch repair and the DNA damage response.
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DOI：
10.1016/j.dnarep.2015.11.019
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发表时间：
2016-02
期刊：
影响因子：
3.8
通讯作者：
Hsieh P
中科院分区：
文献类型：
--
作者：
Li Z;Pearlman AH;Hsieh P
本文综述了DNA错配修复（MMR）在DNA损伤反应（DDR）中的作用，该反应触发细胞周期停滞，在某些情况下，细胞凋亡。虽然重点是从哺乳动物细胞的发现，很多已经从其他生物体，包括细菌和酵母的研究中学到的。MMR促进由关键信号激酶ATM和Rad3相关（ATR）介导的DDR，以响应各种类型的DNA损伤，包括在广泛使用的化疗方案中遇到的一些DNA损伤。ATR介导的DDR的介绍揭示了其巨大的复杂性，并突出了许多生物和机械的问题仍然存在。最新的研究结果和未来的方向是突出。
This review discusses the role of DNA mismatch repair (MMR) in the DNA damage response (DDR) that triggers cell cycle arrest and, in some cases, apoptosis. Although the focus is on findings from mammalian cells, much has been learned from studies in other organisms including bacteria and yeast. MMR promotes a DDR mediated by a key signaling kinase, ATM and Rad3-related (ATR), in response to various types of DNA damage including some encountered in widely used chemotherapy regimes. An introduction to the DDR mediated by ATR reveals its immense complexity and highlights the many biological and mechanistic questions that remain. Recent findings and future directions are highlighted.