How long does the effect of birch pollen injection SIT on apple allergy last?
How long does the effect of birch pollen injection SIT on apple allergy last?
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DOI：
10.1034/j.1398-9995.2003.00139.x
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发表时间：
2003-05-01
期刊：
影响因子：
12.4
通讯作者：
Asero, R
中科院分区：
文献类型：
--
作者：
Asero, R
背景：最近的研究表明，桦树花粉提取物的注射特异性免疫疗法(SIT)极大地减少或治愈了很大比例的桦树花粉过敏患者的相关苹果过敏反应。目的：评价皮下注射白桦花粉提取物对白桦花粉过敏患者苹果过敏的持续时间。方法：对30例临床表现为苹果过敏症状消失，且停用新鲜苹果的白桦花粉过敏患者，从停止注射SIT后6个月开始，每隔12个月随访一次。苹果耐受性以及SPT在所有情况下都进行了评估。57名对桦树花粉过敏、无苹果过敏且未定期随访口腔过敏综合征(OAS)的受试者作为对照。结果：随访30个月后，OAS的总患病率在患者和对照组之间没有差异。虽然随着时间的推移，大多数患者对苹果再次过敏，但在30个月的随访中，50%的患者仍然能够耐受苹果。结论：尽管大多数患者表现出自然的、逐渐的苹果再次过敏倾向(主要致敏原因是长期反复吸入桦树花粉？)，但注射SIT对食物过敏的临床效果似乎相当持久。
Background: Recent studies showed that injection specific immunotherapy (SIT) with birch pollen extract greatly reduces or cures the associated apple allergy in a large proportion of birch pollen-allergic patients. However, the long-term efficacy of SIT for apple allergy has not been assessed.Objective: To evaluate the duration of the effect of injection SIT with birch pollen extract on apple allergy in birch pollen-allergic patients.Methods: Thirty birch pollen-allergic patients showing both the clinical disappearance of apple allergy and a negative SPT with fresh apple at the end of their injection SIT course were followed-up at 12-month intervals from 6 months after SIT was stopped. Apple tolerance as well as SPT was assessed on all occasions. Fifty-seven birch pollen-allergic subjects without apple allergy and not submitted to SIT regularly followed-up for the onset of oral allergy syndrome (OAS) were used as controls.Results: The overall prevalence of OAS after 30 months of follow-up did not differ between patients and controls. Although most patients became re-sensitized to apple by SPT over time, >50% of them were still able to tolerate eating the fruit at the 30-month follow-up visit.Conclusion: Although most patients show a 'natural', gradual propensity to apple re-sensitization (a consequence of prolonged and repeated inhalation of birch pollen responsible for primary sensitization?), the clinical effects of injection SIT on food allergy seem rather long lasting.