A TELOMERIC SEQUENCE IN THE RNA OF TETRAHYMENA TELOMERASE REQUIRED FOR TELOMERE REPEAT SYNTHESIS
A TELOMERIC SEQUENCE IN THE RNA OF TETRAHYMENA TELOMERASE REQUIRED FOR TELOMERE REPEAT SYNTHESIS
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DOI：
10.1038/337331a0
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发表时间：
1989-01-26
期刊：
影响因子：
64.8
通讯作者：
BLACKBURN, EH
中科院分区：
文献类型：
--
作者：
GREIDER, CW;BLACKBURN, EH
四膜虫的端粒酶在没有添加模板的情况下从头合成端粒DNA序列TTGGGG的重复序列。这种核糖核蛋白酶的基本RNA成分现已被克隆，并发现含有CAACCCCAA序列，这似乎是TTGGGG重复序列合成的模板。
The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA component of this ribonucleoprotein enzyme has now been cloned and found to contain the sequence CAACCCCAA, which seems to be the template for the synthesis of TTGGGG repeats.