Low vision and the risk of dementia: a nationwide population-based cohort study
Low vision and the risk of dementia: a nationwide population-based cohort study
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DOI：
10.1038/s41598-020-66002-z
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发表时间：
2020-06-04
影响因子：
4.6
通讯作者：
Na, Kyung-Sun
中科院分区：
文献类型：
--
作者：
Paik, Ji-Sun;Ha, Minji;Na, Kyung-Sun
Recent studies suggested that an association exists between vision loss and cognitive impairment, although it is still vague whether there are causal relationships or direct association between low vision and dementia. We were to investigate the association between low vision and dementia in the Korean population using the National Health Insurance Service (NHIS) database. We analyzed the data of 6,029,657 subjects aged >= 40 years, drawn from Korea National Health Insurance Service. The hazard ratio (HRs) and 95% confidence interval (CIs) of dementia, Alzheimer's disease (AD), and Vascular dementia (VD) were estimated using multivariable Cox proportional hazards regression models. Statistical analysis showed that subjects with more severe visual impairments have a higher risk of dementia, AD, and VD after adjusting for compounding variables. The HRs of dementia increased significantly as visual acuity worsened (HRs 1.444 [95% CIs 1.415-1.473] for visual acuity (VA)
