Nano-Layering Adds Strength to the Adhesive Interface
Nano-Layering Adds Strength to the Adhesive Interface
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DOI：
10.1177/0022034520979133
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发表时间：
2021-05-01
影响因子：
7.6
通讯作者：
Van Meerbeek, B.
中科院分区：
文献类型：
--
作者：
Yoshihara, K.;Nagaoka, N.;Van Meerbeek, B.
X射线衍射（XRD）表面分析和透射电子显微镜（TEM）的超微结构界面表征证实，功能单体10-甲基丙烯酰氧基癸基磷酸二氢酯（10-MDP）自组装成纳米层的粘合剂牙齿界面。自组装纳米层被认为有助于与牙齿牙本质粘合的耐久性，尽管这尚未得到证实。为了揭示这种潜在的键合耐久性的贡献的纳米分层，我们观察了三维（3D）的纳米分层通过一系列的聚焦离子束（FIB）铣削截面扫描电子显微镜（FIB-SEM）和检查的机械性能的自组装纳米分层使用扫描探针显微镜（SPM）。市售含10-MDP的3步自酸蚀粘合剂可部分脱矿牙本质，深度达亚微米，形成亚微米羟基磷灰石富集的混合层。TEM化学和超微结构证实了界面纳米分层的形成。FIB-SEM 3D重建公开了从混合层延伸到相邻粘合剂-树脂层内的自组装纳米分层的3D网络。SPM显示，在粘合剂树脂层内的纳米分层具有比周围的粘合剂树脂的弹性模量更高的弹性模量，由此表明，纳米分层有助于像填料颗粒一样的粘合剂的机械强度。纳米分层的3D扩展结构预计将加强周围的树脂，以及更好地互连粘合剂树脂层的混合层。总之，该探索性研究表明，纳米分层在粘合界面处构成强相，这可能有助于基于10-MDP的牙本质粘合的临床寿命。
X-ray diffraction (XRD) surface analysis and ultrastructural interfacial characterization using transmission electron microscopy (TEM) confirmed that the functional monomer 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) self-assembles into nano-layers at adhesive-tooth interfaces. Self-assembled nano-layering is thought to contribute to the durability of bonding to tooth dentin, although this has not been proven yet. In order to disclose this potential bond-durability contribution of nano-layering, we observed the 3-dimensional (3D) spreading of nano-layering by a series of focused-ion-beam (FIB) milled cross sections by scanning electron microscopy (FIB-SEM) and examined the mechanical properties of self-assembled nano-layering using scanning probe microscopy (SPM). A commercial 10-MDP-containing 3-step self-etch adhesive partially demineralized dentin up to submicron depth, forming a submicron hydroxyapatite-rich hybrid layer. TEM chemically and ultrastructurally confirmed the formation of interfacial nano-layering. FIB-SEM 3D reconstructions disclosed a 3D network of self-assembled nano-layering extending from the hybrid layer up to within the adjacent adhesive-resin layer. SPM revealed that nano-layering within the adhesive-resin layer possessed a higher elastic modulus than that of the surrounding adhesive resin, hereby suggesting that nano-layering contributes to the mechanical strength of adhesives like filler particles do. Nano-layering's 3D expanded structure is expected to strengthen the surrounding resin, as well to better interconnect the adhesive-resin layer to the hybrid layer. In conclusion, this exploratory study demonstrated that nano-layering constitutes a strong phase at the adhesive interface, which may contribute to the clinical longevity of the 10-MDP-based bond to dentin.