[A report of a case with Werner's syndrome suffering from end-stage renal failure].
[A report of a case with Werner's syndrome suffering from end-stage renal failure].
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维尔纳综合征合并终末期肾功能衰竭一例报告[J].
DOI：
10.3143/geriatrics.40.282
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Y. Saito
中科院分区：
文献类型：
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作者：
H. Kawamura;H. Tsuchida;Y. Maezawa;Kazuki Kobayashi;Masaki Fujimoto;S. Asaumi;K. Yokote;S. Mori;Y. Saito
一名54岁的男子在32岁时被发现患有高血压，并在36岁时被诊断为沃纳综合征，当时他被检查为高脂血症。42岁时发现糖尿病。49岁时出现蛋白尿，50岁时出现镜下血尿。51岁时，血清肌酐水平开始升高，腹部CT观察到双侧肾脏萎缩。此后，肾功能逐渐恶化。53岁时，血清肌酐水平升至8.3 mg/dl，出现全身水肿和食欲不振，导致开始血液透析。在Werner综合征中，虽然动脉硬化经常发生，但慢性肾衰竭的病例报告非常罕见。为了研究肾功能不全的原因，进行了肾活检，并对样本进行了组织学检查，发现存在高血压肾小球变化。因此，可以想象，高血压在该病例的肾衰竭进展中发挥了重要作用。
A 54-year-old man was found to have hypertension at age 32, and a diagnosis of Werner's Syndrome was made at age 36 when he was examined for hyperlipidemia. Diabetes mellitus was found at age 42. Proteinuria appeared at age 49, and microscopic hematuria was seen at age 50. At age 51, serum creatinin level began to rise and atrophy of bilateral kidneys was observed by abdominal CT. There after, the renal function gradually worsened. At age 53, the serum creatinin level rose to 8.3 mg/dl, and systemic edema as well as loss of appetite appeared, resulting in the initiation of hemodialysis. In Werner's syndrome, though arteriosclerosis arises frequently, case reports with chronic renal failure are extremely rare. To investigate the cause of the renal dysfunction, renal biopsy was performed and the samples were histologically examined, revealing the presence of hypertensive glomerular changes. It is, thus, conceivable that hypertension had played a major role in the progression of renal failure in this case.
因事先通知的自杀而被认为是内因死亡的案件。
DOI：
--
发表时间：
2020
期刊：
影响因子：
--
作者：
磯部一郎;濱島誠;平田ゆかり;越智拓
通讯作者：
越智拓