Heritability of salt sensitivity in black Americans
Heritability of salt sensitivity in black Americans
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DOI：
10.1161/01.hyp.28.5.854
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发表时间：
1996-11-01
期刊：
影响因子：
8.3
通讯作者：
Wilson, AF
中科院分区：
文献类型：
--
作者：
Svetkey, LP;McKeown, SP;Wilson, AF
盐敏感性被定义为响应于盐和水稳态变化的血压变化。在73%的高血压和36%的血压正常的黑人中发现，它通常被认为是黑人高血压的标志。与白人相比，黑人对盐的敏感性更高，这表明这一特征受到遗传的影响，但几乎没有直接的遗传证据。我们确定了盐敏感性在黑人家庭中的相关程度，并估计了这种表型的遗传力。黑人家庭通过高血压先证者招募。高血压和血压正常的成人表型与盐敏感性与静脉钠负荷，呋塞米容量耗竭协议。盐敏感性被定义为钠负荷血压和容量耗竭血压之间的差异。我们招募了20个家庭，包括30对父母-子女和115对成年兄弟姐妹，盐敏感性动作的平均动脉压、收缩压和舒张压反应的经t检验校正的家族相关性分别为0.33至0.44、0.19至0.37和0.12至0.21。相应的遗传力估计值分别为0.26 ~ 0.84、0.26 ~ 0.74和0.004 ~ 0.24。这些数据强烈表明盐敏感性的遗传成分。
Salt sensitivity is defined as a change in blood pressure in response to changes in salt and water homeostasis. Found in 73% of hypertensive and 36% of normotensive blacks, it is generally considered a hallmark of hypertension in blacks. The higher prevalence of salt sensitivity in blacks compared with whites suggests a genetic influence on this trait, but there is little direct evidence of heritability. We determined the extent to which salt sensitivity is correlated in black families and estimated the heritability of this phenotype. Black families were recruited through a hypertensive proband. Both hypertensive and normotensive adults were phenotyped with respect to salt sensitivity with an intravenous sodium-loading, furosemide volume-depletion protocol. Salt sensitivity was defined as the difference between sodium-loaded and volume-depleted blood pressure. We enrolled 20 families, comprising 30 parent-offspring pairs and 115 adult sibling pairs, Age-adjusted familial correlations ranged from .33 to .44, .19 to .37, and .12 to .21 for mean arterial and systolic and diastolic pressure responses to the salt sensitivity maneuver, respectively. Corresponding heritability estimates were 0.26 to 0.84, 0.26 to 0.74, and 0.004 to 0.24, respectively. These data strongly suggest a heritable component of salt sensitivity.