Postexposure preventive treatment of methylmercury intoxication in rats with dimercaptosuccinic acid.
Postexposure preventive treatment of methylmercury intoxication in rats with dimercaptosuccinic acid.
复制标题
二巯基丁二酸对大鼠甲基汞中毒的暴露后预防性治疗。
DOI：
10.1016/0041-008x(78)90109-6
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发表时间：
1978
影响因子：
3.8
通讯作者：
R. Snowden
中科院分区：
文献类型：
--
作者：
L. Magos;G. C. Peristianis;R. Snowden
Male rats of approximately 200-g body weight were given by gavage six daily doses of 8.0 mg of Hg/kg as Me203HgCl with 2 days omission between the fourth and fifth doses. After five or six doses there was a progressive loss of body weight, followed by granule cells necrosis in the cerebellum and functional disturbances (flailing reflex when animal is held loosely under the forelimbs and crossing of hind legs when animal is held by the tail). Three days of treatment with dimercaptosuccinic acid (DMSA) (75 mg of DMSA/30 ml of drinking water/day/animal) commencing at 1 to 5 days after the last Me203HgCl dose decreased both body burden and the brain contents of203Hg by 60%, reversed loss of body weight, prevented the progression of cerebellar damage, and caused even some improvement in flailing reflex and hind leg crossing. As the brain content of methylmercury reached a maximum between 1 to 3 days, the present experiments indicate that the maximum concentration of methylmercury in the CNS is not the only factor which determines the outcome of methylmercury intoxication; the pattern of methylmercury accumulation and depletion is also an important factor.
