Reduced sweet and fatty fluid intake after Roux-en-Y gastric bypass in rats is dependent on experience without change in stimulus motivational potency
Reduced sweet and fatty fluid intake after Roux-en-Y gastric bypass in rats is dependent on experience without change in stimulus motivational potency
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DOI：
10.1152/ajpregu.00029.2015
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发表时间：
2015-10-15
影响因子：
2.8
通讯作者：
Spector, Alan C.
中科院分区：
文献类型：
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作者：
Mathes, Clare M.;Bohnenkamp, Ryan A.;Spector, Alan C.
在这里，我们评估了如何减少摄入诱导Roux-en-Y胃旁路手术（RYGB）发生在访问期间内和跨检查饮酒的微观结构。训练后，RYGB（n = 8-10）或假手术（SHAM，n = 12）大鼠给予60分钟的机会，首先是0.3 M蔗糖，然后是5%的Intradherid，最后是牛奶巧克力Ensure Plus，各持续5天。最初，RYGB和SHAM大鼠在第一餐蔗糖和Intraperoid期间的总舔食量没有差异，但是，在随后的测试期间，RYGB大鼠的舔食量少于SHAM大鼠。RYGB和SHAM大鼠之间的First Ensure餐量也没有差异，但SHAM大鼠在整个测试期间增加了舔，而RYGB大鼠的行为保持稳定。手术组之间的摄入量差异（当发生时）最常见的原因是RYGB大鼠的爆发量较小。重要的是，蔗糖和Intraperoid摄入量的药物组差异不能解释这些解决方案的适口性改变，因为在整个测试过程中，两组都有类似的早期舔餐行为，被认为代表刺激orosensory功能的动机潜力。尽管总体而言，RYGB大鼠相对于SHAM大鼠显示出较低的Ensure早期进餐舔，但这似乎主要是由后一组在整个测试期间的增加驱动的; RYGB组保持相对稳定。总的来说，这些结果表明，在手术组之间出现摄入差异之前，这些刺激和/或其组分的某种程度的产后经验是必要的，并且，即使出现差异，通常也会立即发生味觉刺激的摄食行为保持不变。
Here we assessed how intake reductions induced by Roux-en-Y gastric bypass surgery (RYGB) occur within and across access periods by examining drinking microstructure. After training, RYGB (n = 8-10) or sham-operated (SHAM, n = 12) rats were given 60-min access first to 0.3 M sucrose, then to 5% Intralipid, and finally to milk-chocolate Ensure Plus across 5 days each. Initially, total licks taken during the first meal of sucrose and Intralipid by RYGB and SHAM rats did not differ, but, across subsequent test periods, RYGB rats licked less than SHAM rats. First Ensure meal size also did not differ between RYGB and SHAM rats, but SHAM rats increased licking across test periods while the behavior of RYGB rats remained stable. The intake differences between the surgical groups, when they occurred, were most often due to smaller burst sizes in RYGB rats. Importantly, the surgical-group difference in sucrose and Intralipid intakes could not be explained by altered palatability of these solutions because, throughout testing, both groups had similar early meal licking behavior thought to represent the motivational potency of stimulus orosensory features. Although, overall, RYGB rats displayed lower early meal licking of Ensure relative to the SHAM rats, this appeared to be driven primarily by increases in the latter group across test periods; the RYGB group stayed relatively stable. Collectively, these results suggest that some level of postoral experience with these stimuli and/or their components is necessary before intake differences emerge between surgical groups, and, even when differences occur, often immediate taste-motivated ingestive behavior remains unaltered.