The sympathetic innervation and adrenoreceptor function of the human lower urinary tract in the normal state and after parasympathetic denervation.
The sympathetic innervation and adrenoreceptor function of the human lower urinary tract in the normal state and after parasympathetic denervation.
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正常状态下和去副交感神经支配后人体下尿路的交感神经支配和肾上腺素受体功能。
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
N. Svedmyr
中科院分区：
文献类型：
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作者：
T. Sundin;A. Dahlström;L. Norlén;N. Svedmyr
在手术期间从六个神经正常膀胱和五个副交感神经失活（下运动神经元病变）膀胱中切除的标本中，对人膀胱的肾上腺素能神经支配进行了体外研究。使用特定的组织化学荧光技术，发现下运动神经元病变患者逼尿肌的肾上腺素能神经末梢比所检查的六个神经正常膀胱中的任何一个都更厚，荧光强度更强，并且在大多数情况下分布更密集。通过记录不同药物治疗后逼尿肌条等长张力的变化，可以证明在副交感神经失活的逼尿肌中存在α-肾上腺素受体，但在正常逼尿肌中则不存在。在七名患有下运动神经元病变的患者体内研究了α-肾上腺素溶解治疗（苯氧苯扎明）的影响。在膀胱测压图中，膀胱的张力更加低，“自主波”出现在较高的充盈水平，或者在这种药物治疗后完全消失。通过等渗体积登记方法，记录α-肾上腺素能阻滞后膀胱体积的增加。使用括约肌测量或尿道压力曲线研究，在α-肾上腺素治疗后观察到尿道阻力下降。
Adrenergic innervation of the human urinary bladder was studied in vitro in specimens excised during operation from six neurologically normal bladders and from five parasympathetically denervated (lower motor neuron lesion) bladders. Using a specific histochemical fluorescence technique, it was found that the adrenergic nerve terminals of the detrusor of the patients with lower motor neuron lesions were thicker, had a stronger fluorescence intensity, and were in most cases also more densely distributed than those of any of the six neurologically normal bladders examined. By recording the changes in the isometric tension of detrusor strips after different pharmacologic treatments, the existence of alpha-adrenergic receptors could be demonstrated in the parasympathetically denervated detrusor but not in the normal detrusor. The influence of alpha-adrenolytic treatment (phenoxybenzamine) was studied in vivo in seven patients with lower motor neuron lesions. In the cystometrograms, the bladders were more hypotonic and the "autonomous waves" appeared at a higher level of filling or were totally extinguished after this pharmacologic treatment. With an isotonic volume registration method, a bladder volume increase was recorded after alpha-adrenergic blockade. Using sphincterometry or urethral pressure profile studies, a decrease in the urethral resistance was observed after alpha-adrenolytic treatment.