Cord blood nesfatin-1 in large for gestational age pregnancies
Cord blood nesfatin-1 in large for gestational age pregnancies
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DOI：
10.1016/j.cyto.2012.10.029
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发表时间：
2013-02-01
期刊：
影响因子：
3.8
通讯作者：
Malamitsi-Puchner, Ariadne
中科院分区：
文献类型：
--
作者：
Boutsikou, Theodora;Briana, Despina D.;Malamitsi-Puchner, Ariadne
目的：研究脐带血脂肪因子nesfatin-1水平的可能变化（由脂肪组织和胰腺β-细胞分泌并涉及葡萄糖代谢和胰岛素抵抗）以及胰岛素，在大（LGA）和适合胎龄（阿加）妊娠中，假定这些组在体脂量和代谢/内分泌机制方面不同。在40名LGA中前瞻性地测量了脐带血nesfatin-1和胰岛素浓度。（9名糖尿病母亲和31名非糖尿病母亲）和20名阿加单胎足月婴儿及其母亲。LGA新生儿的脐带血nesfatin-1浓度显著低于阿加新生儿（B =-0.206，SE 0.07，p = 0.005）。然而，在对照组后，与非糖尿病母亲所生的婴儿相比，患有妊娠期糖尿病（GDM）的母亲所生的婴儿的脐带血nesfatin-1浓度升高（B = 0.190，SE 0.10，p = 0.05）。最后，脐带血nesfatin-1浓度较低的情况下，阴道分娩（B = 0.11，SE 0.05，p = 0.042）。随着定制百分位数的增加，胰岛素水平显著升高（B = 0.004，SE = 0.002，p = 0.016）。胰岛素和nesfatin-1之间没有显着的相关性被发现在母亲和脐带levels.Conclusions：在这项研究中，nesfatin-1水平下降LGA相比，阿加胎儿。胎儿nesfatin-1浓度较高的情况下，GDM和脐带血nesfatin-1浓度较低的情况下，阴道分娩。(c)2012爱思唯尔有限公司保留所有权利。
Objective: To investigate possible alterations in cord blood levels of adipokine nesfatin-1 (secreted by adipose tissue and pancreatic beta-cells and implicated in glucose metabolism and insulin resistance), as well as insulin, in large (LGA) and appropriate for gestational age (AGA) pregnancies, granted that these groups differ in body fat mass and metabolic/endocrine mechanisms.Materials and methods: Cord blood nesfatin-1 and insulin concentrations were prospectively measured in 40 LGA (9 born from diabetic and 31 from non-diabetic mothers) and 20 AGA singleton full-term infants as well as their mothers.Results: Cord blood nesfatin-1 concentrations were significantly lower in LGA compared to AGA neonates (b = -0.206, SE 0.07, p = 0.005). However, cord blood nesfatin-1 concentrations were elevated in infants born from mothers with gestational diabetes mellitus (GDM), compared to those born from non-diabetic mothers, after controlling for group (b = 0.190, SE 0.10, p = 0.05). Finally, cord blood nesfatin-1 concentrations were lower in cases of vaginal delivery (b = 0.11, SE 0.05, p = 0.042). Insulin levels were significantly elevated, as customized centiles increased (b = 0.004, SE = 0.002, p = 0.016). No significant correlation was found between insulin and nesfatin-1 in maternal and umbilical cord levels.Conclusions: In this study nesfatin-1 levels are decreased in LGA compared to AGA fetuses. Fetal nesfatin-1 concentrations are higher in cases of GDM and cord blood nesfatin-1 concentrations are lower in cases of vaginal delivery. (c) 2012 Elsevier Ltd. All rights reserved.