CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity
CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity
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DOI：
10.1016/s0092-8674(00)81637-2
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发表时间：
1998-11-25
期刊：
影响因子：
64.5
通讯作者：
Rosbash, M
中科院分区：
文献类型：
--
作者：
Emery, P;So, WV;Rosbash, M
光是昼夜节律的主要环境信号。我们鉴定并分析了cry，一种新型果蝇隐花色素基因。所有特征化的家族成员都是直接感光的，并且包括植物蓝光感光器。我们发现，哭泣转录受到昼夜节律调节，受到果蝇时钟基因 period、timeless、Clock 和 Cycle 的影响。我们还表明，哭泣蛋白水平受到光照的显着影响。重要的是，过度表达哭泣的菌株的昼夜节律光敏感性增加。因此，这些生理和遗传数据将特定的光感受器分子与昼夜节律联系起来。结合随附论文中的数据，我们认为 CRY 是果蝇的主要光感受器，致力于重置昼夜节律。
Light is a major environmental signal for circadian rhythms. We have identified and analyzed cry, a novel Drosophila cryptochrome gene. All characterized family members are directly photosensitive and include plant blue light photoreceptors. We show that cry transcription is under circadian regulation, influenced by the Drosophila clock genes period, timeless, Clock, and cycle. We also show that cry protein levels are dramatically affected by light exposure. Importantly, circadian photosensitivity is increased in a cry-overexpressing strain. These physiological and genetic data therefore link a specific photoreceptor molecule to circadian rhythmicity. Taken together with the data in the accompanying paper, we propose that CRY is a major Drosophila photoreceptor dedicated to the resetting of circadian rhythms.