Long-term outcomes and toxicities of carbon-ion radiotherapy in malignant tumors of the sphenoid sinus
Long-term outcomes and toxicities of carbon-ion radiotherapy in malignant tumors of the sphenoid sinus
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DOI：
10.1002/hed.25965
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发表时间：
2020-01-01
影响因子：
2.9
通讯作者：
Tsuji, Hiroshi
中科院分区：
文献类型：
--
作者：
Hagiwara, Yasuhito;Koto, Masashi;Tsuji, Hiroshi
背景：大多数原发性蝶窦肿瘤表现为局部晚期，累及邻近关键结构，不适合根治性切除。我们试图评估碳离子放射治疗（c离子RT）治疗蝶窦恶性肿瘤的安全性和有效性。结果：腺样囊性癌是最常见的组织学类型（15例，68.2%）。该队列的中位随访为48.5个月。5年精算局部控制率和总生存率分别为51.0%和62.7%。4级视力损害6例，4级脑坏死1例。结论：c -离子放射治疗局部晚期蝶窦恶性肿瘤的临床效果较好，但由于靶体积与关键结构非常接近，晚期毒性谱略高。
Background: Most of the primary sphenoid sinus tumors present with locally advanced stages with involvement of adjacent critical structures and are not amenable to radical resection. We sought to evaluate the safety and efficacy of carbonion radiotherapy (C-ion RT) for sphenoid sinus malignancies.Methods: This is a retrospective analysis of 22 patients of primary sphenoid carcinomas treated with definitive C-ion RT.Results: Adenoid cystic carcinoma was the most common histology (15 patients, 68.2%). The median follow-up of this cohort was 48.5 months. The actuarial local control and overall survival at 5 years were 51.0% and 62.7%, respectively. Grade 4 visual impairment and grade 4 brain necrosis were seen in six and one patient, respectively.Conclusion: C-ion RT can provide a reasonably good clinical outcome in locally advanced sphenoid sinus malignancies with a marginally higher late toxicity profile because of extremely close proximity of the target volume to critical structures.