Association of chronic hepatitis B virus infection with preterm birth: our experience and meta-analysis
Association of chronic hepatitis B virus infection with preterm birth: our experience and meta-analysis
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DOI：
10.1515/jpm-2016-0201
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发表时间：
2017-11-01
影响因子：
2.4
通讯作者：
Cheng, Xiao-Yan
中科院分区：
文献类型：
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作者：
Cui, Ai-Min;Shao, Jian-Guo;Cheng, Xiao-Yan
目的：为探讨慢性B肝炎病毒（HBV）感染与早产（PTB）的关系，选择南通大学妇产科医院20,498例孕妇，其中HBV携带者497例，非HBV对照者20,001例。比较HBV携带者与非HBV感染者的临床指标及PTB发生率。对于荟萃分析，我们搜索了PubMed，奥维德和科克伦图书馆数据库的研究比较PTB的发病率之间的个人与慢性HBV感染和非HBV subjects.Results：HBV携带者年龄稍大，ALT水平略高，在正常范围内。HBV携带者与非HBV携带者的体重指数、文化程度和妊娠史具有可比性。在我们的队列中，PTB发病率与HBV携带状态无关[相对危险度（RR）0.98，95%置信区间（CI）0.71-1.37]。然而，荟萃分析涉及8个已发表的研究和我们的研究显示，慢性HBV感染和PTB的发病率之间的显着关联（合并RR 1.26，95%CI 1.19-1.33）。结论：虽然母亲HBV携带者并没有在我们的队列PTB的发病率较高，荟萃分析表明，个人与慢性HBV感染似乎是在PTB的风险作为一个整体。
Objectives: To assess the association of chronic hepatitis B virus (HBV) infection with preterm birth (PTB).Methods: A cohort of 20,498 pregnant women (497 HBV carriers with 20,001 non-HBV controls) with normal alanine aminotransferase (ALT) levels was selected from the Obstetrics & Gynecology Hospital of Nantong University. The clinical parameters and PTB incidence were compared between HBV carriers and non-HBV subjects. For the meta-analysis, we searched the PubMed, Ovid and Cochrane Library databases for studies comparing PTB incidence between individuals with chronic HBV infection and non-HBV subjects.Results: HBV carriers were slightly older and had slightly higher ALT levels within normal limits. The body mass index, education and history of pregnancy between HBV carrier and non-HBV groups were comparable. PTB incidence was not associated with HBV carrier status [relative risk (RR) 0.98, 95% confidence interval (CI) 0.71-1.37] in our cohort. However, the meta-analysis involving eight published studies and our study revealed a significant association between chronic HBV infection and PTB incidence (pooled RR 1.26, 95% CI 1.19-1.33).Conclusion: While maternal HBV carriers did not have a higher incidence of PTB in our cohort, the meta-analysis indicates that individuals with chronic HBV infection appeared to be at risk of PTB as a whole.