Contrast-enhanced ultrasonography depicts small tumor vessels for the evaluation of pancreatic tumors
Contrast-enhanced ultrasonography depicts small tumor vessels for the evaluation of pancreatic tumors
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DOI：
10.1016/j.ejrad.2006.08.014
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发表时间：
2007-01-01
影响因子：
3.3
通讯作者：
Shiratori, Yasushi
中科院分区：
文献类型：
--
作者：
Okamoto, Yuko;Kawamoto, Hirofumi;Shiratori, Yasushi
目的：本研究的目的是评价超声造影对胰腺肿瘤的诊断效果。 材料和方法：连续对 62 例患者（53 例胰腺癌、4 例胰岛细胞瘤、3 例炎性胰腺肿瘤、2 例转移性肿瘤）进行 Levovist 超声造影。对肿瘤的血管和灌注图像阶段进行评估，并与增强计算机断层扫描的结果进行比较。结果：79%的胰腺癌患者（42/53）在血管图像阶段，增强超声检查显示肿瘤周围和/或肿瘤血管。在灌注图像阶段，96%（51/53）的胰腺癌被归类为低增强型。然而，84%的低强化胰腺癌患者发现微小点状或不规则异质强化病灶（43/51）。血管图像阶段小血管的存在与灌注图像阶段这些瘤内区域增强病灶的存在密切相关（K系数= 0.42）。超声造影对胰腺癌的敏感性（100%）优于增强计算机断层扫描（91%），但两者之间没有观察到显着差异（McNemar 检验：p = 0.063）。结论：Levovis 超声造影成功地显示了胰腺肿瘤的细血管和强化情况，对于评估胰腺肿瘤很有用。 (C) 2006 Elsevier Ireland Ltd. 保留所有权利。
Objective: The aim of this study is to evaluate the efficacy of contrast-enhanced ultrasonography for the diagnosis of pancreatic tumors.Materials and methods: Contrast-enhanced ultrasonography with Levovist was performed on 62 consecutive patients (53 with pancreatic cancer, 4 with islet cell tumor, 3 with inflammatory pancreatic tumor, and 2 with metastatic tumor). The vascular and perfusion image phases of the tumors were evaluated and compared with the findings of contrast-enhanced computed tomography.Results: Contrast-enhanced ultrasonography showed tumor vessels around and/or in the tumor at the vascular image phase in 79% of pancreatic cancer patients (42/53). At the perfusion image phase, 96% of pancreatic cancers (51/53) were classified as hypo-enhancement type. However, tiny spotty or irregular heterogeneous enhanced lesions were found in 84% of hypo-enhanced pancreatic cancer patients (43/51). The presence of small vessels at the vascular image phase was closely correlated with the presence of these intratumor regional enhanced lesions at the perfusion image phase (K coefficient = 0.42). The sensitivity of contrast-enhanced ultrasonography (100%) for pancreatic cancer was superior to that of contrast-enhanced computed tomography (91%), but no significant difference was observed between the two (McNemar test: p = 0.063).Conclusion: Contrast-enhanced ultrasonography with Levovist successfully visualizes fine vessels and enhancement in pancreatic tumors, and is useful for evaluating pancreatic tumors. (C) 2006 Elsevier Ireland Ltd. All rights reserved.