Body Mass Index in Children Validated by Metabolic and Fat Mass Profiling
Body Mass Index in Children Validated by Metabolic and Fat Mass Profiling
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通过代谢和脂肪量分析验证儿童体重指数
DOI：
10.1016/j.jacc.2018.10.016
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发表时间：
2018
影响因子：
24
通讯作者：
Mäkinen V
中科院分区：
文献类型：
--
作者：
Mäkinen V
在本期杂志中，贝尔等人。(1)报告关于青少年肥胖和心脏代谢危险因素之间相互作用的纵向研究结果，以及作为肥胖筛查工具的体重指数（BMI）的质量。这一研究领域之所以重要，有几个原因。首先，健康生活的基础是在青年时期建立的，但由于缺乏数据，未成年人群的心脏代谢特征的最新轨迹往往不确定，这使得制定循证干预措施和健康标准变得更加困难。人们也可以争论，几十年前预防心血管疾病的计划是否有意义;心脏代谢功能障碍的分子病因学的完整纵向图将澄清问题。其次，青年肥胖预示着成年后的心脏代谢功能障碍（2）。不幸的是，我们作为一个社会-家庭，教育工作者，社区领导人和其他人-未能遏制儿童肥胖率。未来50年，当久坐和超重的儿童逐渐患上糖尿病和血管并发症时，会发生什么？第三，减肥和行为改变在致肥胖环境中很难实现，但也许肥胖引起的代谢压力可以在贝尔等人收集的高保真代谢数据的帮助下减轻。（一）.即使是“肥胖但健康”
In this issue of the Journal, Bell et al.(1) report longitudinal findings on the interactions between adolescent fatness and cardiometabolic risk factors and the quality of the body mass index (BMI) as the established screening tool for fatness. This area of research is important for several reasons. First, the foundations of a healthy life are set in youth, but up-to-date trajectories of cardiometabolic traits are often uncertain in underage population segments because of lack of data, which makes it harder to develop evidence-based interventions and health criteria. It can also be argued whether prevention programs against cardiovascular disease decades beforehand make sense; a complete longitudinal picture of the molecular etiology of cardiometabolic dysfunction would clarify matters. Second, obesity in youth predicts cardiometabolic dysfunction in adulthood (2). Unfortunately, we as a society—families, educators, community leaders, and others alike—are failing to curb rates of childhood obesity (Figure 1). What will happen in the next 50 years when the sedentary and overweight children graduate to diabetes and vascular complications?Third, weight loss and changes in behavior are hard to achieve in an obesogenic environment, but maybe the metabolic stress from obesity can be mitigated with the help of high-fidelity metabolic data such as those collected by Bell et al.(1). Even the “fat but fit”