Immunohistochemical Study of Vesicle Monoamine Transporter 2 in the Hippocampal Region of Genetic Animal Model of Schizophrenia
Immunohistochemical Study of Vesicle Monoamine Transporter 2 in the Hippocampal Region of Genetic Animal Model of Schizophrenia
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DOI：
10.1002/syn.20846
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发表时间：
2010-12-01
期刊：
影响因子：
2.3
通讯作者：
Ozaki, Norio
中科院分区：
文献类型：
--
作者：
Iritani, Shuji;Sekiguchi, Hirotaka;Ozaki, Norio
最近对精神分裂症病因学的研究表明，这种疾病的大脑中可能存在一些神经发育障碍，例如神经元网络功能不全，神经递质无法准确或充分发挥作用。但是，目前还不清楚组织病理学上可能存在什么样的神经传递缺陷。我们研究了在神经传递中具有重要作用的囊泡单胺转运蛋白2（VMAT2）在精神分裂症动物模型14-3-3ε杂基因敲除（KO）小鼠海马形成中的表达，采用免疫组化染色技术来阐明模型动物中的神经元异常。结果，与野生型同窝小鼠相比，14-3-3ε异质KO小鼠海马结构中VMAT2的表达显着增加。总之，根据对转基因小鼠作为精神分裂症模型的研究，这些发现可能与这种疾病的病理生理学有关，包括单胺能传递异常。 Synapse 64:948-953, 2010。(C)2010 Wiley-Liss, Inc.
Recent research in the etiology of schizophrenia revealed that there may be some neurodevelopmental failures such as neuronal network incompetence in the brain of this disease, and neurotransmitters cannot function accurately or adequately. But, it is unknown precisely what kinds of deficit in neurotransmission may be existed histopathologically. We investigated the expression of vesicle monoamine transporter 2 (VMAT2), which has a significant role in neurotransmission, in the hippocampal formation of the animal model of schizophrenia, 14-3-3epsilon hetero knockout (KO) mouse, using an immunohistochemical staining technique to clarify the neuronal abnormalities in the model animal. As a result, the expression of VMAT2 was increased significantly in the hippocampal formation of 14-3-3epsilon hetero KO mice compared to that of the wild-type littermates. In conclusion, these findings might be related the pathophysiology of this disease includes a monoaminergic transmission abnormality, based on the investigation in a genetically-modified mouse as schizophrenic model. Synapse 64:948-953, 2010. (C)2010 Wiley-Liss, Inc.