3D dosimetry for proton therapy
3D dosimetry for proton therapy
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质子治疗的 3D 剂量测定
DOI：
10.1088/1742-6596/1305/1/012038
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
S. Beddar
中科院分区：
文献类型：
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作者：
S. Beddar
我们一直在开发新的三维（3D）检测器系统，使用有机塑料和液体稀释剂，以测量和成像的剂量分布，从质子治疗束在近实时。已经进行了使用单个电荷耦合器件照相机的概念验证和初步可行性研究。我们最近的研究集中在用于患者治疗的扫描质子束的表征上，使用基于3D液体闪烁器的检测器系统，该系统具有一组科学互补金属氧化物半导体（sCMOS）相机。基本概念包括使用大体积的固体或液体闪烁体来测量或成像来自3D质子束的剂量分布。我们最近开发了一种基于大型液体闪烁体的探测器系统，该系统由一个20 x 20 x 20 cm的透明丙烯酸罐组成，其中装满了水当量的市售液体闪烁体，当用质子照射时会产生闪烁光。为了跟踪点扫描质子束中的快速空间和剂量变化，我们使用3台高速sCMOS相机以电影模式对来自3个正交投影的闪烁光信号进行成像。此外，我们开发了一种新的图像采集方法，使相机成像时间与动态双光束传输同步，以有效捕获剂量，从而实现准确的剂量计算。该系统在德克萨斯大学MD安德森癌症中心的质子治疗中心得到充分开发和表征。我们表明，这样的系统可以提供快速和准确的测量范围，横向轮廓，和横向位置的扫描质子束具有良好的空间分辨率（0.21毫米）。我们还证明，此类探测器可以快速测量多种能量的质子束特征和强度，这使它们成为扫描质子束系统、束质量保证研究和验证患者治疗交付的理想工具。
We have been developing novel 3-dimensional (3D) detector systems using organic plastic and liquid scintillators to measure and image the dose distribution from proton therapy beams in near-real time. Proof-of-concept and initial feasibility studies using a single charge-coupled device camera have already been conducted. Our recent studies focused on the characterization of scanning proton beams used for patient treatments using a 3D liquid scintillator-based detector system with a set of scientific-complementary metal-oxide-semiconductor (sCMOS) cameras. The basic concept consists of using a large volume of a solid or liquid scintillator to measure or image the dose distributions from proton beams in 3D. We recently developed a large liquid scintillator-based detector system consisting of a 20 × 20 × 20cm transparent acrylic tank filled with a water-equivalent, commercially available liquid scintillator that generates scintillation light when irradiated with protons. To track rapid spatial and dose variations in spot-scanned proton beams, we used 3 high-speed sCMOS cameras to image the scintillation light signals from 3 orthogonal projections in cine mode. Furthermore, we developed a new image acquisition approach that synchronized camera imaging times with dynamic pencil-beam deliveries to efficiently capture the dose and therefore enable accurate dosimetric calculations. This system was fully developed and characterized at the Proton Therapy Center at The University of Texas MD Anderson Cancer Center. We show that such systems can provide fast and accurate measurements of the range, lateral profile, and lateral position of scanning proton beams with excellent spatial resolution (0.21 mm). We also demonstrate that such detectors can rapidly measure proton beam characteristics and intensities at multiple energies, which makes them an ideal tool for scanned proton-beam systems, beam quality assurance studies, and verification of patient treatment delivery.