Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes
Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes
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DOI：
10.7554/elife.46418
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发表时间：
2019-07-08
期刊：
影响因子：
7.7
通讯作者：
Brunet, Anne
中科院分区：
文献类型：
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作者：
Booth, Lauren N.;Maures, Travis J.;Brunet, Anne
性互动对包括哺乳动物在内的几个物种的健康有着强大的影响。以前的工作在C。秀丽线虫发现了雄性用来加速异性（雌雄同体）灭亡的策略。但雌雄同体是否进化出了对抗雄性的策略仍不清楚。在这里，我们发现年轻的C。秀丽线虫雌雄同体对与雄性的短暂性接触有显著的抵抗力，而年长的雌雄同体过早地屈服。令人惊讶的是，保护年轻两性人的不是他们的年轻，而是他们有自我精子的事实。自体精子的有益作用是通过作用于索马的精子感应途径介导的，而不是通过受精。女性激活这一通路可以保护女性免受男性的负面影响。有趣的是，自体精子在保护雄性线虫免受有害影响方面的作用在两性线虫中独立进化。延迟交配负面影响的内源性策略可能代表了最大限度地提高生殖成功率的关键进化创新。
Sexual interactions have a potent influence on health in several species, including mammals. Previous work in C. elegans identified strategies used by males to accelerate the demise of the opposite sex (hermaphrodites). But whether hermaphrodites evolved counter-strategies against males remains unknown. Here we discover that young C. elegans hermaphrodites are remarkably resistant to brief sexual encounters with males, whereas older hermaphrodites succumb prematurely. Surprisingly, it is not their youthfulness that protects young hermaphrodites, but the fact that they have self-sperm. The beneficial effect of self-sperm is mediated by a sperm-sensing pathway acting on the soma rather than by fertilization. Activation of this pathway in females triggers protection from the negative impact of males. Interestingly, the role of self-sperm in protecting against the detrimental effects of males evolved independently in hermaphroditic nematodes. Endogenous strategies to delay the negative effect of mating may represent a key evolutionary innovation to maximize reproductive success.