SELECTIVE TRANSLATION AND DEGRADATION OF HEAT-SHOCK MESSENGER-RNAS IN DROSOPHILA
SELECTIVE TRANSLATION AND DEGRADATION OF HEAT-SHOCK MESSENGER-RNAS IN DROSOPHILA
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DOI：
10.1159/000468754
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发表时间：
1990-01-01
期刊：
影响因子：
--
通讯作者：
PETERSEN, R
中科院分区：
文献类型：
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作者：
LINDQUIST, S;PETERSEN, R
热休克蛋白的快速和戏剧性诱导是由许多不同水平的调控机制完成的。在这里，我们回顾了果蝇黑腹果蝇在反应过程中使用的两种细胞质机制的现有知识。(1)热休克信息在热休克过程中被高效地翻译，而大多数正常细胞信息是不活跃的。热激mRNAs 5‘-未翻译前导序列控制其优先翻译。(2)热休克蛋白的信息在正常温度下不稳定。然而，在热震期间，它们非常稳定，并大量积累。其3‘-非翻译区的序列在决定其稳定性方面起着重要作用。
The rapid and dramatic induction of heat-shock proteins is accomplished by regulatory mechanisms acting at many different levels. Here we review current knowledge of two cytoplasmic mechanisms employed during the response in the fruit fly Drosophila melanogaster. (1) Heat-shock messages are translated with high efficiency during heat shock while most normal cellular messages are inactive. Sequences in the 5'-untranslated leader of heat shock mRNAs govern their preferential translation. (2) The messages for heat-shock proteins are unstable at normal temperatures. During heat shock, however, they are very stable and accumulate in large numbers. Sequences in their 3'-untranslated regions play a major role in determining their stability.