Coordinated dynamic encoding in the retina using opposing forms of plasticity.
Coordinated dynamic encoding in the retina using opposing forms of plasticity.
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DOI：
10.1038/nn.2906
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发表时间：
2011-09-11
影响因子：
25
通讯作者：
Baccus SA
中科院分区：
文献类型：
--
作者：
Kastner DB;Baccus SA
神经元编码的自然输入的范围经常超过其动态范围。为了克服这一限制，神经细胞群体将它们的输入划分为不同的细胞类别，就像杆状和锥状感光器一样，并通过改变其动态范围来适应。我们报道，火蜥蜴、小鼠和兔子的视网膜神经节细胞的动态行为被分为两种不同细胞类别的短期可塑性的相反形式。一组细胞表现出敏感化--强烈刺激后敏感度持续升高。这种新颖的动态行为补偿了发生在单独细胞群体中的已知适应过程造成的信息损失。这两个群体划分了输入的动态范围，敏化细胞编码弱信号，适应细胞编码强信号。在这两个群体中，线性、阈值和适应性属性被联系在一起，以在刺激统计数据发生变化时保持反应能力，其中一个群体保持在另一个群体失败时做出反应的能力。
The range of natural inputs encoded by a neuron often exceeds its dynamic range. To overcome this limitation, neural populations divide their inputs among different cell classes, as with rod and cone photoreceptors, and adapt by shifting their dynamic range. We report that the dynamic behavior of retinal ganglion cells in salamanders, mice, and rabbits is divided into two opposing forms of short-term plasticity in different cell classes. One population of cells exhibited sensitization—a persistent elevated sensitivity following a strong stimulus. This novel dynamic behavior compensates for the information loss caused by the known process of adaptation occurring in a separate cell population. The two populations divide the dynamic range of inputs, with sensitizing cells encoding weak signals, and adapting cells encoding strong signals. In the two populations, the linear, threshold and adaptive properties are linked to preserve responsiveness when stimulus statistics change, with one population maintaining the ability to respond when the other fails.
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影响因子：
16.2
作者：
Mennerick, S;Matthews, G
通讯作者：
Matthews, G
影响因子：
--
作者：
Pelli, DG
通讯作者：
Pelli, DG
影响因子：
16.2
作者：
Nagel, Katherine I.;Doupe, Allison J.
通讯作者：
Doupe, Allison J.
影响因子：
9.8
作者：
Maravall M;Petersen RS;Fairhall AL;Arabzadeh E;Diamond ME
通讯作者：
Diamond ME
影响因子：
7.8
作者：
Butts, DA
通讯作者：
Butts, DA