Digital image analysis in retinopathy of prematurity: A comparison of vessel selection methods
Digital image analysis in retinopathy of prematurity: A comparison of vessel selection methods
复制标题
DOI：
10.1016/j.jaapos.2011.11.015
复制
发表时间：
2012-06-01
期刊：
影响因子：
1.6
通讯作者：
Fielder, Alistair R.
中科院分区：
文献类型：
--
作者：
Wilson, Clare M.;Wong, Karen;Fielder, Alistair R.
目的评价血管选择方法，半自动地从数字视网膜图像中量化相关血管的宽度和弯曲变化，以区分有无早产儿视网膜病变(ROP)和不同时期的ROP。方法对75例ROP婴儿的彩色数字图像进行标准直径240像素的裁剪，并用计算机辅助视网膜图像分析软件(CAIAR)进行评估，以测量视网膜血管宽度和弯曲程度。血管选择采用两种方法：(1)临床观察者选择每个视网膜象限最突出的小动脉或小静脉(4-血管分析)，然后从每个象限分别选择最突出的4个小动脉或小静脉(8-血管分析)；(2)CAIAR选择最宽或最弯曲的4个小动脉或小静脉，而不考虑视网膜象限。结果无论是观察者还是CAIAR选择的ROP分期，以及是否分析了4或8支血管，我们发现ROP分期进展时，0期与2期、0期或1期与3期、1+2期与3期、0期与1+2+3期合并时，微动脉弯曲程度显著增加(P<；0.01)。随着ROP分期的进展，0期患者的静脉曲度显著大于3期患者和0期患者，而合并1期和2+3期患者的患者则明显增多(P<；0.01)。宽度参数不能帮助我们区分不同的分期。结论在使用CAIAR时，不需要区分微动脉和小静脉来区分0期ROP和2期或3期ROP。在提供可靠的血管参数来区分无ROP和有ROP的眼睛方面，曲折比宽度显示出更多的希望。(美国AAPOS杂志2012；16：223-228)
PURPOSE To evaluate vessel selection methods to distinguish between eves with and without retinopathy of prematurity (ROP) and between different stages of ROP when quantifying the associated vessel changes in width and tortuosity semiautomatically from digital retinal images.METHODS Color digital images from 75 infants screened for ROP were cropped to a standardized diameter of 240 pixels and evaluated by semiautomated vessel analysis software, Computer-Aided Image Analysis of the Retina (CAIAR), to measure retinal vessel width and tortuosity. Two methods of vessel selection were used: (1) clinical observer selecting the most prominent arteriole or venule in each retinal quadrant (4-vessel analysis) and then separately the 4 most prominent arterioles and venules from each quadrant (8-vessel analysis); (2) CAIAR selecting, regardless of retinal quadrant, the 4 widest or most tortuous arterioles or venules. Selected vessels were measured by CAIAR for tortuosity and width.RESULTS When comparing ROP stages, whether observer or CAIAR selected and whether 4 or 8 vessels were analyzed, we found that arteriolar tortuosity was significantly greater with advancing ROP stage for stage 0 versus stage 2; stage 0 or 1 versus stage 3; stages 1+2 combined versus stage 3; and stage 0 versus 1+2+3 combined (P < 0.01). Venular tortuosity was significantly greater with advancing ROP stage for stage 0 versus stage 3 and stage 0 versus stages 1 and 2+3 combined (P < 0.01). Width parameters did not help us to distinguish between stages.CONCLUSIONS Distinguishing between arterioles and venules is not necessary to differentiate stage 0 ROP from stage 2 or 3 ROP when one is using CAIAR. Tortuosity shows more promise than width at providing a reliable vessel parameter for distinguishing between eyes without and with ROP. (J AAPOS 2012;16:223-228)