Randomised clinical trial showing the curative effect of bandaging on M2-stage lesions of digital dermatitis in dairy cows
Randomised clinical trial showing the curative effect of bandaging on M2-stage lesions of digital dermatitis in dairy cows
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DOI：
10.1136/vetreco-2017-000264
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发表时间：
2019-01-01
影响因子：
1.4
通讯作者：
Mueller, Kerstin Elisabeth
中科院分区：
文献类型：
--
作者：
Klawitter, Marcus;Dopfer, Dorte;Mueller, Kerstin Elisabeth
目的与设计本试验采用两种不同的局部治疗方法，评价包扎治疗奶牛急性疼痛性牛指端溃疡性皮炎(M2期)皮损的效果。设计随机临床试验。研究对象为同一奶牛群中年龄从小母牛到第四次哺乳的荷斯坦-弗里斯奶牛，在第一次检查(0周)时被诊断为急性溃疡性DD皮损(M2期)。奶牛在两种处理条件下随机分为未包扎组和包扎组：外用金霉素喷雾剂(CTC)和蹄内凝胶(IHF)。皮损每周接受标准化的包扎和治疗。未愈合的损伤可以在四周内每周间隔接受最多五次重复治疗。每周对M期和运动能力进行评估和评分。皮肤形成健康(M0期)的奶牛被认为是愈合的，随后从研究中释放。结果总共有163个M2病变在0周时被诊断出来。无论治疗类型如何，包扎的M2皮损均显著高于未包扎的皮损(HR：4.1；P
Objectives and design This trial evaluated the effect of bandaging of acute painful ulcerative bovine digital dermatitis (DD) lesion (stage M2) in dairy cows, tested using two different topical treatments.Design Randomised clinical trial.Setting This study was conducted using Holstein-Friesian cows ranging in age from heifers to fourth lactation in a single dairy herd and diagnosed with acute ulcerative DD lesions (stage M2) on the first examination (week 0). Cows were randomly assigned into either a non-bandaged or bandaged group across two treatment conditions: topical chlortetracycline spray (CTC) and Intra Hoof-Fit Gel (IHF). Lesions received standardised bandaging and treatment on a weekly basis. Unhealed lesions could receive up to five repeated treatments, at weekly intervals, within a four-week period. Both M-stage and locomotion were also evaluated and scored weekly. Cows with healthily formed skin (stage M0) were deemed healed and subsequently released from the study.Results In total, 163 M2 lesions were diagnosed at week 0. Bandaged M2 lesions had a significantly higher probability of cure than non-bandaged lesions regardless of treatment type (HR: 4.1; P