ER stress response: Getting the UPR hand on misfolded proteins
ER stress response: Getting the UPR hand on misfolded proteins
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DOI：
10.1016/s0960-9822(00)00583-2
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发表时间：
2000-07-13
期刊：
影响因子：
9.2
通讯作者：
Hampton, RY
中科院分区：
文献类型：
--
作者：
Hampton, RY
未折叠的蛋白质不断被输送到内质网腔，在那里它们必须通过折叠或降解被去除。最近的研究表明，“未折叠蛋白反应”基本上控制着内质网功能的所有方面，在正常细胞生命所必需的过程中协调错误折叠蛋白的这两种命运。
Unfolded proteins are constantly delivered to the ER lumen, where they must be removed by folding or degradation. Recent studies show that the 'unfolded protein response' controls essentially all aspects of ER function, coordinating these two fates for misfolded proteins in a process necessary for normal cell life.