Preinflammatory Signs in Established Reusable and Disposable Contact Lens Wearers
Preinflammatory Signs in Established Reusable and Disposable Contact Lens Wearers
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DOI：
10.1097/opx.0000000000001129
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发表时间：
2017-11-01
影响因子：
1.4
通讯作者：
Richdale, Kathryn
中科院分区：
文献类型：
--
作者：
Chao, Cecilia;Stapleton, Fiona;Richdale, Kathryn
重要性：已确定的可重复使用角膜接触透镜（CL）配戴者在标准软性CL覆盖的区域显示出较高的泪液炎性细胞因子浓度和较高的结膜化生。平衡的促炎抗炎细胞因子，但不是个人的眼泪细胞因子浓度，与自我报告的CL insufficient.Purpose：日抛（DD）镜片通常用于改善CL不适，但对眼部炎症反应的影响尚未得到充分研究。本研究旨在比较泪液细胞因子和结膜细胞形态的浓度在健康习惯DD和可重复使用的软CL wearers.METHODS：36个建立每日CL配戴者，包括14 DD和24可重复使用的配戴者，被招募。评价症状和眼表完整性。使用多重测定法测定泪液细胞因子（白细胞介素1 β [IL-1 β]、IL-6、IL-10、IL-12（p70）、IL-17 A和肿瘤坏死因子α）的浓度。计算促炎和抗炎细胞因子的比率。对结膜进行印模细胞学检查，并对杯状细胞密度和上皮鳞状化生进行定量。分析不同CL更换时间表的变量差异以及变量之间的相关性。可重复使用CL配戴者的浓度较高IL-1 β（pg/mL）（26 +/- 7 vs. 16 +/- 11），IL-6（42 +/- 14 vs. 25 +/- 20），IL-10（83 +/- 23 vs. 49 +/- 36），IL-12（p70）IL-17 A（93 +/- 26 vs. 54 +/-44）和肿瘤坏死因子a（312 [171 - 468] vs. 189 [6 - 447]）（均P
SIGNIFICANCE: Established reusable contact lens (CL) wearers show higher tear inflammatory cytokine concentrations and greater conjunctival metaplasia in the region covered by standard soft CLs. The balance of proinflammatory to anti-inflammatory cytokines, but not individual tear cytokine concentrations, was associated with self-reported CL discomfort.PURPOSE: Daily disposable (DD) lenses are often used to improve CL discomfort, but the effect on ocular inflammatory responses has not been fully investigated. This study aimed to compare the concentrations of tear cytokines and conjunctival cell morphology in healthy habitual DD and reusable soft CL wearers.METHODS: Thirty-six established daily CL wearers, including 14 DD and 24 reusable wearers, were enrolled. Symptoms and ocular surface integrity were evaluated. The concentration of tear cytokines (interleukin 1 beta [IL-1 beta], IL-6, IL-10, IL-12(p70), IL-17A, and tumor necrosis factor a) were determined using Multiplex assays. The ratios of proinflammatory and anti-inflammatory cytokines were calculated. Impression cytology was performed on the conjunctiva, and goblet cell density and epithelial squamous metaplasia were quantified. Differences in variables by CL replacement schedules and the associations between variables were analyzed.RESULTS: Reusable CL wearers had higher concentrations (in pg/mL) of IL-1 beta (26 +/- 7 vs. 16 +/- 11), IL-6 (42 +/- 14 vs. 25 +/- 20), IL-10 (83 +/- 23 vs. 49 +/- 36), IL-12(p70) (145 +/- 44 vs. 91 +/- 68), IL-17A (93 +/- 26 vs. 54 +/- 44), and tumor necrosis factor a (312 [171 to 468] vs. 189 [6 to 447]) (all P