Endothelin action on pituitary lactotrophs: one receptor, many GTP-binding proteins.

Endothelin action on pituitary lactotrophs: one receptor, many GTP-binding proteins.
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DOI:
10.1126/stke.3192006pe4
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发表时间:
2006-01-24
期刊:
Science's STKE : signal transduction knowledge environment
影响因子:
--
通讯作者:
Freeman, Marc E
Freeman, Marc E
中科院分区:
其他
文献类型:
--
作者:
Bertram, Richard;Tabak, Joel;Freeman, Marc E

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内皮素是一类荷尔蒙家族,对脑下垂体促乳素细胞有双相作用。最初的作用是刺激性的,随后是抑制,在激动剂被移除后很长一段时间内持续存在。最近的研究已经发现了几个介导这些效应的G蛋白途径。
The endothelins are a family of hormones that have a biphasic action on pituitary lactotrophs. The initial effect is stimulatory, followed later by inhibition that persists long after the agonist has been removed. Recent research has uncovered several G protein pathways that mediate these effects.