Hypnosis control based on the minimum concentration of anesthetic drug for maintaining appropriate hypnosis.
Hypnosis control based on the minimum concentration of anesthetic drug for maintaining appropriate hypnosis.
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基于维持适当催眠的麻醉药物最低浓度的催眠控制。
DOI：
10.1109/embc.2013.6610292
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Shirakami G.
中科院分区：
文献类型：
--
作者：
Furutani E;Nishigaki Y;Kanda C;Takeda T;Shirakami G.
本文提出了一种以听觉诱发电位指数（aepEX）作为催眠指标的催眠控制方法。为了避免麻醉药物的副作用，在手术中减少麻醉药物的用量是可取的。为了这个目的，许多催眠控制系统的研究已经完成。它们大多使用另一种催眠指标——双谱指数（BIS），但它存在对麻醉药物的依赖性和在某些特定值附近变化不平稳的问题。另一方面，aepEX具有明确区分患者意识和无意识以及麻醉药物独立性的能力。本文提出的控制方法包括两个部分：估计维持适当催眠的最小效应点浓度和使用模型预测控制调节麻醉药物异丙酚的输注速率。利用aepEX药效学特性估计最小效应位点浓度。调整异丙酚的输注速率，使异丙酚的效区浓度接近并始终高于最低效区浓度。应用该方法进行催眠控制的仿真结果表明，所提控制方法能合理地估计最小浓度，能充分维持催眠状态，减少异丙酚的总输注量。
This paper proposes a novel hypnosis control method using Auditory Evoked Potential Index (aepEX) as a hypnosis index. In order to avoid side effects of an anesthetic drug, it is desirable to reduce the amount of an anesthetic drug during surgery. For this purpose many studies of hypnosis control systems have been done. Most of them use Bispectral Index (BIS), another hypnosis index, but it has problems of dependence on anesthetic drugs and nonsmooth change near some particular values. On the other hand, aepEX has an ability of clear distinction between patient consciousness and unconsciousness and independence of anesthetic drugs. The control method proposed in this paper consists of two elements: estimating the minimum effect-site concentration for maintaining appropriate hypnosis and adjusting infusion rate of an anesthetic drug, propofol, using model predictive control. The minimum effect-site concentration is estimated utilizing the property of aepEX pharmacodynamics. The infusion rate of propofol is adjusted so that effect-site concentration of propofol may be kept near and always above the minimum effect-site concentration. Simulation results of hypnosis control using the proposed method show that the minimum concentration can be estimated appropriately and that the proposed control method can maintain hypnosis adequately and reduce the total infusion amount of propofol.