INHIBITION OF ATTACHMENT OF STREPTOCOCCUS-PNEUMONIAE AND HAEMOPHILUS-INFLUENZAE BY HUMAN-MILK AND RECEPTOR OLIGOSACCHARIDES
INHIBITION OF ATTACHMENT OF STREPTOCOCCUS-PNEUMONIAE AND HAEMOPHILUS-INFLUENZAE BY HUMAN-MILK AND RECEPTOR OLIGOSACCHARIDES
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DOI：
10.1093/infdis/153.2.232
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发表时间：
1986-02-01
影响因子：
6.4
通讯作者：
SVANBORGEDEN, C
中科院分区：
文献类型：
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作者：
ANDERSSON, B;PORRAS, O;SVANBORGEDEN, C
母乳抑制肺炎链球菌和流感嗜血杆菌附着在人咽或颊上皮细胞上。牛奶和水牛奶等婴儿配方奶粉对肺炎球菌的抑制活性较低，并增强了流感嗜血杆菌的粘附力。在牛奶的高分子量和低分子量部分中都发现了针对肺炎链球菌的抗粘附作用。高分子量部分的抑制活性与特异性抗体含量无关；它存在于免疫吸附后以及 IgA 缺陷女性的轻度症状中。低分子量部分的抑制活性部分是由对应于糖脂新乳糖系列碳水化合物部分的寡糖含量来解释的，这些寡糖先前已被证明可作为附着肺炎球菌的受体。针对流感嗜血菌的抗粘附活性仅限于牛奶的高分子量部分，并且不受免疫吸附的影响。牛奶可以通过减少定植来预防中耳炎。
Human milk inhibited the attachment of Streptococcus pneumoniae and Haemophilus influenzae to human pharyngeal or buccal epithelial cells. Infants formulas as cow and buffalo milk showed a lower inhibitory activity against pneumococci and enhanced the adhesion of H. influenzae. The antiadhesive effect against S. pneumoniae was found in both the high- and the low-molecular-weight fractions of milk. The inhibitory activity in the high-molecular-weight fraction was independent of specific antibody content; it was present after immunoadsorption and in the mild from IgA-deficient women. The inhibitory activity in the low-molecular-weight fraction was in part explained by the content of oligosaccharides corresponding to the carbohydrate moieties of the neolactoseries of glycolipids, which have previously been shown to act as receptors for attaching pneumococci. the antiadhesive activity against H. influezae was restricted to the high-molecular-weight fraction of the milk and was unaffected by immunoadsorption. Milk may protect against otitis by reducing colonization.