(-)-Hydroxylindestrenolide, a New Sesquiterpenoid from a Gorgonian Coral Menella sp (Plexauridae)
(-)-Hydroxylindestrenolide, a New Sesquiterpenoid from a Gorgonian Coral Menella sp (Plexauridae)
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DOI：
10.1248/cpb.59.1048
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发表时间：
2011-08-01
影响因子：
1.7
通讯作者：
Sung, Ping-Jyun
中科院分区：
文献类型：
--
作者：
Kao, Shih-Yao;Chang, Yu-Chia;Sung, Ping-Jyun
(-)-羟基茚内酯 (1) 是已知倍半萜类化合物 (+)-羟基茚内酯 (2) 的对映体，是从被鉴定为 Menella sp. 的柳珊瑚中分离出来的。通过光谱方法并通过与2的光谱和物理数据比较，确定了1的结构，包括相对立体化学。倍半萜1对HL-60和K562白血病肿瘤细胞表现出边缘细胞毒性，并且在浓度为10μg/ml时对人中性粒细胞产生超氧阴离子显示出微弱的抑制作用。
(-)-Hydroxylindestrenolide (1), an enantiomer of the known sesquiterpenoid, (+)-hydroxylindestrenolide (2), was isolated from a gorgonian coral identified as Menella sp. The structure, including the relative stereochemistry of 1 was established by spectroscopic methods and by comparison the spectral and physical data with those of 2. Sesquiterpenoid 1 exhibited marginal cytotoxicity toward HL-60 and K562 leukemia tumor cells, and displayed a weak inhibitory effect on superoxide anion generation at a concentration of 10 mu g/ml by human neutrophils.