Neoplastic transformation of cells in vitro at low and high dose rates of fission neutrons: an interpretation.
Neoplastic transformation of cells in vitro at low and high dose rates of fission neutrons: an interpretation.
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低和高裂变中子剂量率下体外细胞的肿瘤转化：一种解释。
DOI：
10.1080/09553008514552711
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
M. Chesters
中科院分区：
文献类型：
--
作者：
P.R.J. Burch;M. Chesters
Hill等人的意外发现（1984年），其中OTI/2细胞在裂变谱中子的低剂量和低剂量率下的诱导转化频率比在高剂量率下的要大得多，引起了人们的极大兴趣，甚至有些怀疑（Barendsen 1985年）。在低剂量率下，剂量-效应关系在0 ~ 10 cGy范围内呈有效线性;（B）0 ~ 40 cGy高剂量率照射，加剧了上述矛盾（Barendsen 1985，Elkind和Hill 1985）。这两个剂量-反应关系的总体形式使我们想起了我们已经研究过的两个方程的特征（Burch和Chesters 1979），一个来自Haynes（1966）的辐射细菌存活的修复模型，另一个来自我们的辐射诱导修复的纯推测模型。我们认为在这里可能的相关性，这两个模型和第三个，更一般的版本相结合的功能，希尔等人的数据。（1984年）。
Unexpected findings of Hill et al.(1984), in which the induced transformation frequency of OTI/2 cells at low dose and low dose rate of fission-spectrum neutrons is much larger per unit dose than at high dose rate, have excited much interest and even some scepticism (Barendsen 1985). That the dose-response relation appears to be effectively linear:(a) over the dose range 0 to 10 cGy at low dose rate; and (b) from 0 to 40cGy at high dose rate, heightens the paradox (Barendsen 1985, Elkind and Hill 1985).The overall form of the two dose-response relations reminded us of the characteristics of two equations we had already investigated (Burch and Chesters 1979), one deriving from Haynes's (1966) repair model for the survival of irradiated bacteria and the other from our purely speculative model of radiation-induced repair. We consider here the possible relevance of these two models and a third, more general version combining the features of both, to the data of Hill et al.(1984).
低剂量率的裂变谱中子增强线性低剂量区域（0-10 cGy）的肿瘤转化。
DOI：
10.1080/09553008414551011
发表时间：
1984
期刊：
International journal of radiation biology and related studies in physics, chemistry, and medicine
影响因子：
--
作者：
Hill,CK;Han,A;Elkind,MM
通讯作者：
Elkind,MM